Uniform-sized molecularly imprinted polymer for (S)-ibuprofen -: Retention properties in aqueous mobile phases

被引:86
|
作者
Haginaka, J [1 ]
Sanbe, H [1 ]
Takehira, H [1 ]
机构
[1] Mukogawa Womens Univ, Fac Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan
关键词
molecular imprinting; chiral stationary phases; LC; ibuprofen; 2-hydroxyibuprofen; 2-carboxyibuprofen;
D O I
10.1016/S0021-9673(99)00764-5
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A uniform-sized molecularly imprinted polymer for (S)-ibuprofen has been prepared by a multi-step swelling and thermal polymerization method using 4-vinylpyridine (4-VPY) and ethylene glycol dimethacrylate (EDMA) as a host functional monomer and cross-linker, respectively. The obtained (S)-ibuprofen imprinted 4-VPY-EDMA materials were evaluated using aqueous eluents by HPLC. Hydrophobic and hydrogen bonding interactions between ibuprofen enantiomers and 4-VPY-EDMA materials could play an important role in the retentivity and enantioselectivity. Further, partial resolution of the enantiomers of ibuprofen metabolites, 2-hydroxy- and 2-carboxyibuprofen, was attained with the (S)-ibuprofen imprinted 4-VPY-EDMA materials. (C) 1999 Elsevier Science BN. All rights reserved.
引用
收藏
页码:117 / 125
页数:9
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