Uniform-sized molecularly imprinted polymer for (S)-ibuprofen -: Retention properties in aqueous mobile phases

被引：86

作者：

Haginaka, J ^{[1
]}

Sanbe, H ^{[1
]}

Takehira, H ^{[1
]}

机构：

[1] Mukogawa Womens Univ, Fac Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan

来源：

JOURNAL OF CHROMATOGRAPHY A | 1999年 / 857卷 / 1-2期

关键词：

molecular imprinting; chiral stationary phases; LC; ibuprofen; 2-hydroxyibuprofen; 2-carboxyibuprofen;

D O I：

10.1016/S0021-9673(99)00764-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A uniform-sized molecularly imprinted polymer for (S)-ibuprofen has been prepared by a multi-step swelling and thermal polymerization method using 4-vinylpyridine (4-VPY) and ethylene glycol dimethacrylate (EDMA) as a host functional monomer and cross-linker, respectively. The obtained (S)-ibuprofen imprinted 4-VPY-EDMA materials were evaluated using aqueous eluents by HPLC. Hydrophobic and hydrogen bonding interactions between ibuprofen enantiomers and 4-VPY-EDMA materials could play an important role in the retentivity and enantioselectivity. Further, partial resolution of the enantiomers of ibuprofen metabolites, 2-hydroxy- and 2-carboxyibuprofen, was attained with the (S)-ibuprofen imprinted 4-VPY-EDMA materials. (C) 1999 Elsevier Science BN. All rights reserved.

引用

页码：117 / 125

页数：9

共 12 条

[1] Molecularly imprinted uniform-sized polymer-based stationary phase for naproxen - Comparison of molecular recognition ability of the molecularly imprinted polymers prepared by thermal and redox polymerization techniques [J].