Synthesis, Crystal Structure and Anti-parasitic Activity of 2-(2-Methoxy-4-nitrophenylcarbamoyl)phenyl 4-Fluorobenzoate

被引：0

作者：

Duan Li-Ping ^{[1
]}

Wu Ning-Bo ^{[1
]}

Liu Cong-Shan ^{[1
]}

Tao Yi ^{[1
]}

Zhang Xue-Qiang ^{[1
]}

Zhang Hao-Bing ^{[1
]}

机构：

[1] Chinese Ctr Dis Control & Prevent, Natl Inst Parasit Dis, Key Lab Parasitol & Vector Biol, Shanghai 200025, Peoples R China

来源：

CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 2013年 / 32卷 / 06期

关键词：

2-(2-methoxy-4-nitrophenylcarbamoyl)phenyl-4 '-fluorobenzoate; synthesis; anti-parasitic; crystal structure; ECHINOCOCCOSIS; CHEMOTHERAPY; ALBENDAZOLE;

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The title compound 2-(2-methoxy-4-nitrophenylcarbamoyl)phenyl-4'-fluorobenzoate (C21H15FN2O6, M-r = 410.35), a fluorine-containing derivative of salicylamide, was conveniently synthesized through two steps and crystallized in the orthorhombic space group P2(1)/c with a = 7.6453(15), b = 14.323(3), c = 17.035(3) angstrom, V = 1865.4(6) angstrom(3), Z = 4, D-c = 1.461 Mg/m(3), lambda = 0.71073 angstrom, mu(MoK alpha) = 0.115 mm(-1), F(000) = 848, R = 0.0705 and wR = 0.1834 for 3267 independent reflections with I > 2 sigma(I). X-ray analysis reveals that the dihedral angles formed between the 2-methoxy-4-nitrobenzene and benzene ring, the benzene and 4-fluorobenzene, and the 2-methoxy-4-nitrobenzene and 4-fluorobenzene ring are 3.2(4), 69.8(3) and 72.9(2)degrees, respectively. Bioassay shows that the title compound has anti-parasitic activity against hydatid protoscoleces.

引用

页码：847 / 852

页数：6

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