Double-positive CD4/CD8 mycosis fungoides: a rarely reported immunohistochemical profile

被引：17

作者：

Tournier, Emilie ^{[1
]}

Laurent, Camille ^{[1
,2
]}

Thomas, Marianne ^{[3
]}

Meyer, Nicolas ^{[3
]}

Viraben, Roland ^{[3
]}

Brousset, Pierre ^{[1
,2
,4
]}

Lamant, Laurence ^{[1
,2
,4
]}

机构：

[1] CHU Purpan, Lab Anat Pathol, F-31300 Toulouse, France

[2] Univ Toulouse 3, F-31062 Toulouse, France

[3] Larrey Hosp, CHU Toulouse, Dept Dermatol, Toulouse, France

[4] CRCT, INSERM, U1037, Toulouse, France

来源：

JOURNAL OF CUTANEOUS PATHOLOGY | 2014年 / 41卷 / 01期

关键词：

mycosis fungoides; confocal microscopy; immunohistochemistry; T-cell phenotype; CUTANEOUS LYMPHOMAS; EXPRESSION; VARIANT; PHENOTYPE;

D O I：

10.1111/cup.12248

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Mycosis fungoides (MF) represents the most common epidermotropic cutaneous T-cell lymphoma (CTCL), and tumor cells typically express a mature T-helper memory phenotype. A minority of MF patients display an unusual phenotype, which may be either CD4(-)/CD8(+) or double negative. Herein, we report a case of biopsy-proven MF in a 31-year-old woman who presented with infiltrated plaques involving photoprotected areas of the skin. Immunohistochemical study combined with confocal microscopy revealed co-expression of CD4 and CD8 in a subset of atypical T lymphocytes. To our knowledge, this is the second report of a CD4/CD8 dual-positive MF.

引用

页码：58 / 62

页数：5

共 14 条

[1] Primary cutaneous CD8-positive epidermotropic cytotoxic T cell lymphomas - A distinct clinicopathological entity with an aggressive clinical behavior
Berti, E
Tomasini, D
Vermeer, MH
Meijer, CJLM
Alessi, E
Willemze, R
[J]. AMERICAN JOURNAL OF PATHOLOGY, 1999, 155 (02) : 483 - 492
[2] El Shabrawi-Caelen L, 2002, AM J SURG PATHOL, V26, P450
[3] El-Darouti MA, 2006, EUR J DERMATOL, V16, P17
[4] CD4/CD8 double-negative epidermotropic cutaneous T-cell lymphoma: An immunohistochemical variant of mycosis fungoides
Hodak, Emmilia
David, Michael
Maron, Leah
Aviram, Adina
Kaganovsky, Ella
Feinmesser, Meora
[J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2006, 55 (02) : 276 - 284
[5] Expression Patterns of the Immunosuppressive Proteins PD-1/CD279 and PD-L1/CD274 at Different Stages of Cutaneous T-Cell Lymphoma/Mycosis Fungoides
Kantekure, Kanchan
Yang, Yusong
Raghunath, Puthiyaveettil
Schaffer, Andras
Woetmann, Anders
Zhang, Qian
Odum, Niels
Wasik, Mariusz
[J]. AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2012, 34 (01) : 126 - 128
[6] CD4/CD8 Double Negative Mycosis Fungoides With PD-1 (CD279) Expression-A Disease of Follicular Helper T-Cells?
Kempf, Werner
Kazakov, Dmitry V.
Cipolat, Claudio
Kutzner, Heinz
Roncador, Giovanna
Tomasini, Dario
[J]. AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2012, 34 (07) : 757 - 761
[7] CD4/CD8 Dual-Positive Mycosis Fungoides: A Previously Unrecognized Variant
Knapp, Charles F.
Mathew, Rahel
Messina, Jane L.
Lien, Mary H.
[J]. AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2012, 34 (03) : E37 - E39
[8] The prognosis of early mycosis fungoides is not influenced by phenotype and T-cell clonality
Massone, C.
Crisman, G.
Kerl, H.
Cerroni, L.
[J]. BRITISH JOURNAL OF DERMATOLOGY, 2008, 159 (04) : 881 - 886
[9] Value of the CD8-CD3 ratio for the diagnosis of mycosis fungoides
Ortonne, N
Buyukbabani, N
Delfau-Larue, MH
Bagot, M
Wechsler, J
[J]. MODERN PATHOLOGY, 2003, 16 (09) : 857 - 862
[10] Petit T, 2003, EUR J DERMATOL, V13, P410

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