Neurogenomics of speech and language disorders: the road ahead

被引：23
作者：
Deriziotis, Pelagia [1 ]
Fisher, Simon E. [1 ,2 ]
机构：
[1] Max Planck Inst Psycholinguist, NL-6525 XD Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 EN Nijmegen, Netherlands
来源：
GENOME BIOLOGY | 2013年 / 14卷 / 04期
关键词：
exome; genome; FOXP2; functional validation; language; next-generation sequencing; neurodevelopmental disorders; speech; DE-NOVO MUTATIONS; CHILDHOOD-APRAXIA; INHERITED SPEECH; FOXP2; EXPRESSION; INTELLECTUAL DISABILITY; DEVELOPMENTAL SPEECH; MENTAL-RETARDATION; GENETIC-BASIS; AUTISM; IMPAIRMENT;
D O I：
10.1186/gb-2013-14-4-204
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Next-generation sequencing is set to transform the discovery of genes underlying neurodevelopmental disorders, and so off er important in sights into the biological bases of spoken language. Success will depend on functional assessments in neuronal cell lines, animal models and humans themselves.
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页数：12
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