Effect of HIF1A Gene Polymorphism on Human Muscle Performance

被引:41
作者
Ahmetov, I. I. [1 ,2 ]
Hakimullina, A. M. [2 ]
Lyubaeva, E. V. [1 ]
Vinogradova, O. L. [1 ]
Rogozkin, V. A. [2 ]
机构
[1] Russian Acad Sci, Inst Biomed Problems, Moscow, Russia
[2] Russian Acad Sci, St Petersburg Inst Phys Culture, Moscow, Russia
关键词
HIF1A; polymorphism; muscle fibers; muscular activity;
D O I
10.1007/s10517-008-0291-3
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Allele distribution of hypoxia-inducible factor gene (HIF1A; Pro582Ser polymorphism) was studied in power-oriented athletes and controls practicing no athletics; genotype relationships with muscle fiber composition were studied in speed skaters. Genotyping was carried out by PCR. The composition of muscle fibers was evaluated by the immunohistochemical analysis of m. vastus lateralis. The incidence of HIF1A Ser allele was significantly higher in weight-lifters than in controls (17.9 vs. 8.5%; p=0.001) and increased with athletic skill improvement. A relationship between HIF1A Ser allele and predominance of fast-twitch muscle fibers was shown (Pro/Ser 46.2 (13.8)%, Pro/Pro 31.4 (8.2)%; p=0.007). Hence, HIF1A Pro582Ser polymorphism is associated with muscle activity in humans.
引用
收藏
页码:351 / 353
页数:3
相关论文
共 12 条
[1]  
Ahmetov II, 2006, ROS FIZIOL ZH, V92, P883
[2]   Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: Novel pathways and targets for anticancer therapeutics [J].
Airley, Rachel E. ;
Mobasheri, Ali .
CHEMOTHERAPY, 2007, 53 (04) :233-256
[3]  
BOLLA MK, 1995, CLIN CHEM, V41, P1599
[4]   The pVHL-associated SCF ubiquitin ligase complex:: Molecular genetic analysis of elongin B and C, Rbx1 and HIF-1α in renal cell carcinoma [J].
Clifford, SC ;
Astuti, D ;
Hooper, L ;
Maxwell, PH ;
Ratcliffe, PJ ;
Maher, ER .
ONCOGENE, 2001, 20 (36) :5067-5074
[5]   Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway [J].
Huang, LE ;
Gu, J ;
Schau, M ;
Bunn, HF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (14) :7987-7992
[6]   Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α [J].
Iyer, NV ;
Kotch, LE ;
Agani, F ;
Leung, SW ;
Laughner, E ;
Wenger, RH ;
Gassmann, M ;
Gearhart, JD ;
Lawler, AM ;
Yu, AY ;
Semenza, GL .
GENES & DEVELOPMENT, 1998, 12 (02) :149-162
[7]   Skeletal muscle HIF-1α expression is dependent on muscle fiber type [J].
Pisani, DF ;
Dechesne, CA .
JOURNAL OF GENERAL PHYSIOLOGY, 2005, 126 (02) :173-178
[8]   Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1 [J].
Semenza, GL ;
Jiang, BH ;
Leung, SW ;
Passantino, R ;
Concordet, JP ;
Maire, P ;
Giallongo, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (51) :32529-32537
[9]   Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations [J].
Sutter, CH ;
Laughner, E ;
Semenza, GL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (09) :4748-4753
[10]   Hypoxia-inducible factor-1α polymorphisms associated with enhanced transactivation capacity, implying clinical significance [J].
Tanimoto, K ;
Yoshiga, K ;
Eguchi, H ;
Kaneyasu, M ;
Ukon, K ;
Kumazaki, T ;
Oue, N ;
Yasui, W ;
Imai, K ;
Nakachi, K ;
Poellinger, L ;
Nishiyama, M .
CARCINOGENESIS, 2003, 24 (11) :1779-1783