Gelatin-Alginate Gels and Their Enzymatic Modifications: Controlling the Delivery of Small Molecules

被引：27

作者：

Klak, Marie-Cecile ^{[1
]}

Lefebvre, Elodie ^{[1
]}

Remy, Laure ^{[1
]}

Agniel, Remy ^{[1
]}

Picard, Julien ^{[2
]}

Giraudier, Sebastien ^{[2
]}

Larreta-Garde, Veronique ^{[1
]}

机构：

[1] Univ Cergy Pontoise, ERRMECe Lab, PRES UPGO, I MAT, F-95000 Cergy Pontoise, France

[2] Maia Woundcare, F-95000 Cergypontoise, France

来源：

MACROMOLECULAR BIOSCIENCE | 2013年 / 13卷 / 06期

关键词：

alginate; drug delivery; gel network; gelatin; SUSTAINED-RELEASE; HYDROGELS; PROTEOLYSIS; TRANSITION; DIFFUSION; GROWTH;

D O I：

10.1002/mabi.201200386

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The release of molecules entrapped within biogels is dictated by diffusion laws. Innovative biogel architectures are conceived and tested to control small molecule delivery from gelatin gels. The ionic interactions modulate the release of small molecules. Alginate is then added to gelatin gels and further hydrolyzed; the influence of viscosity is discussed. Next, various mixed gels are compared, such as a gelatin-alginate IPN and the original architecture of an alginate gel entrapped in a gelatin gel with or without a polysaccharidase. The relative influence of ionic interactions and diffusional constraints on the delivery of small charged molecules is explored, and a solution for controlling diffusion is proposed for any situation.

引用

页码：687 / 695

页数：9

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