Reference values of 25-hydroxyvitamin D revisited: a position statement from the Brazilian Society of Endocrinology and Metabolism (SBEM) and the Brazilian Society of Clinical Pathology/ Laboratory Medicine (SBPC)

被引：23

作者：

Moreira, Carolina Aguiar ^{[1
,2
,3
]}

Ferreira, Carlos Eduardo dos S. ^{[4
,5
,6
]}

Madeira, Miguel ^{[1
,7
]}

Carvalho Silva, Barbara Campolina ^{[1
,8
,9
]}

Maeda, Sergio Setsuo ^{[1
,10
]}

Batista, Marcelo Cidade ^{[4
,5
]}

Bandeira, Francisco ^{[1
,11
]}

Cochenski Borba, Victoria Z. ^{[1
,2
]}

Lazaretti-Castro, Marise ^{[1
,10
]}

机构：

[1] Soc Brasileira Endocrinol & Metabol SBEM, Dept Metab Osseo, Rio De Janeiro, RJ, Brazil

[2] Univ Fed Parana SEMPR, Serv Endocrinol & Metabol, Hosp Clin, Curitiba, Parana, Brazil

[3] Fundacao Pro Renal, Lab PRO, Unidade Histomorfometria Ossea, Curitiba, Parana, Brazil

[4] Soc Brasileira Patol Clin Med Lab SBPC ML, Rio De Janeiro, RJ, Brazil

[5] Hosp Israelita Albert Einstein, Dept Patol Clin, Med Diagnost & Ambulatorial MDA, Sao Paulo, SP, Brazil

[6] Univ Fed Sao Paulo EPM Unifesp, Disciplina Med Lab, Lab Cent, Sao Paulo, SP, Brazil

[7] Univ Fed Rio de Janeiro UFRJ, Unidade Endocrinol, Rio De Janeiro, RJ, Brazil

[8] Hosp Felicio Rocho & Santa Casa Belo Horizonte, Unidade Endocrinol, Belo Horizonte, MG, Brazil

[9] Ctr Univ Belo Horizonte UNI BH, Disciplina Endocrinol, Belo Horizonte, MG, Brazil

[10] Univ Fed Sao Paulo EPM Unifesp, Escola Paulista Med, Disciplina Endocrinol, Sao Paulo, SP, Brazil

[11] Univ Pernambuco UPE, Fac Med, Div Endocrinol & Diabet, Recife, PE, Brazil

来源：

ARCHIVES OF ENDOCRINOLOGY METABOLISM | 2020年 / 64卷 / 04期

关键词：

Vitamin D; 25-hydroxyvitamin D; reference range; vitamin D intoxication; VITAMIN-D SUPPLEMENTATION; BONE-MINERAL DENSITY; DWELLING OLDER-ADULTS; SERUM PARATHYROID-HORMONE; D-RECEPTOR EXPRESSION; D-BINDING PROTEIN; D DEFICIENCY; POSTMENOPAUSAL WOMEN; DOUBLE-BLIND; D ASSAYS;

D O I：

10.20945/2359-3997000000258

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hypovitaminosis D is a common condition with a negative impact on health.This statement, prepared by experts from the Brazilian Society of Endocrinology and Metabolism and the Brazilian Society of Clinical Pathology/Laboratory Medicine, includes methodological aspects and limitations of the measurement of 25-hydroxyvitamin D [25(OH)D] for identification of vitamin D status, and identifies individuals at increased risk for deficiency of this vitamin in whom 25(OH)D measurement is recommended. For the general population, 25(OH)D levels between 20 and 60 ng/mL are considered normal, while individuals with levels below 20 ng/mL are considered to be vitamin D deficient. This statement identifies potential benefits of maintaining 25(OH)D levels > 30 ng/mL in specific conditions, including patients aged > 65 years or pregnant, those with recurrent falls, fragility fractures, osteoporosis, secondary hyperparathyroidism, chronic kidney disease, or cancer, and individuals using drugs with the potential to affect the vitamin D metabolism. This statement also calls attention to the risk of vitamin D intoxication, a life-threatening condition that occurs at 25(OH) D levels above 100 ng/mL.

引用

页码：462 / 478

页数：17

共 141 条

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