MiR-222 in Cardiovascular Diseases: Physiology and Pathology

被引：53

作者：

Ding, Shengguang ^{[1
]}

Huang, Haitao ^{[1
]}

Xu, Yiming ^{[1
]}

Zhu, Hao ^{[1
]}

Zhong, Chongjun ^{[1
]}

机构：

[1] Nantong Univ, Affiliated Hosp 2, Dept Thorac & Cardiovasc Surg, Nantong 226001, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2017年 / 2017卷

关键词：

STEM-CELLS; MICRORNA; EXPRESSION; EXERCISE; CANCER; TRANSCRIPTION; RESISTANCE; SIGNATURE; PROTECTS; INJURY;

D O I：

10.1155/2017/4962426

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

MicroRNAs (miRNAs and miRs) are endogenous 19-22 nucleotide, small noncoding RNAs with highly conservative and tissue specific expression. They can negatively modulate target gene expressions through decreasing transcription or posttranscriptional inducing mRNA decay. Increasing evidence suggests that deregulated miRNAs play an important role in the genesis of cardiovascular diseases. Additionally, circulating miRNAs can be biomarkers for cardiovascular diseases. MiR-222 has been reported to play important roles in a variety of physiological and pathological processes in the heart. Here we reviewed the recent studies about the roles of miR-222 in cardiovascular diseases. MiR-222 may be a potential cardiovascular biomarker and a new therapeutic target in cardiovascular diseases.

引用

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