GAP chemistry for pyrrolyl coumarin derivatives: a highly efficient one-pot synthesis under catalyst-free conditions

被引：69
作者：
Wang, Huiyan [1 ,2 ]
Liu, Xuecheng [1 ]
Feng, Xian [1 ]
Huang, Zhibin [1 ]
Shi, Daqing [1 ]
机构：
[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China
[2] Huaihai Inst Technol, Dept Chem Engn, Lianyungang 222005, Peoples R China
来源：
GREEN CHEMISTRY | 2013年 / 15卷 / 12期
关键词：
FORMAL TOTAL-SYNTHESIS; SPIROOXINDOLE DERIVATIVES; POLYSUBSTITUTED PYRROLES; REGIOSELECTIVE SYNTHESIS; 3-COMPONENT REACTION; N; S-KETENE ACETAL; DOMINO REACTION; ACCESS; COPPER; KNORR;
D O I：
10.1039/c3gc41799a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A concise and efficient one-pot synthesis of pyrrolyl coumarin derivatives via a four-component reaction of 4-hydroxycoumarin, arylglyoxal monohydrate, dialkyl but-2-ynedioate and amines under catalyst-free conditions in an environmentally friendly medium (ethanol) is described. This synthesis was confirmed to follow the group-assisted-purification (GAP) chemistry process, which can avoid traditional chromatography and recrystallization purification methods.
引用
收藏
页码：3307 / 3311
页数：5
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