Uronium salts from polymeric N-hydroxysuccinimide (P-HOSu) as new solid-supported peptide coupling reagents

被引:14
作者
Chinchilla, R [1 ]
Dodsworth, DJ [1 ]
Nájera, C [1 ]
Soriano, JM [1 ]
Yus, M [1 ]
机构
[1] Univ Alicante, Fac Ciencias, Dept Quim Organ, Apartado 99, E-03080 Alicante, Spain
关键词
uronium salts; peptides; polymers; coupling reagents;
D O I
10.3998/ark.5550190.0004.a06
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The new polymeric uronium salts P-TSTU and P-HSTU have been prepared from polymeric N-hydroxysuccinimide (P-HOSu) and used as solid-supported reagents for peptide coupling reactions. The P-HOSu liberated can be recovered by simple filtration and reused for the preparation of new reagents.
引用
收藏
页码:41 / 47
页数:7
相关论文
共 44 条
[1]  
Abdelmoty Iman, 1994, Letters in Peptide Science, V1, P57, DOI 10.1007/BF00126274
[2]  
Aiswaryakumari K, 1998, POLYM INT, V45, P255, DOI 10.1002/(SICI)1097-0126(199803)45:3<255::AID-PI904>3.0.CO
[3]  
2-N
[4]   EFFICIENT COUPLING OF ALPHA,ALPHA-DIMETHYL AMINO-ACID USING A NEW CHLORO IMIDAZOLIDIUM REAGENT, CIP [J].
AKAJI, K ;
KURIYAMA, N ;
KISO, Y .
TETRAHEDRON LETTERS, 1994, 35 (20) :3315-3318
[5]  
Albericio F, 2001, ORG PREP PROCED INT, V33, P205
[6]   Forming stable helical peptides using natural and artificial amino acids [J].
Andrews, MJI ;
Tabor, AB .
TETRAHEDRON, 1999, 55 (40) :11711-11743
[7]   2-mercaptopyridone 1-oxide-based uronium salts:: New peptide coupling reagents [J].
Bailén, MA ;
Chinchilla, R ;
Dodsworth, DJ ;
Nájera, C .
JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (24) :8936-8939
[8]  
BENOITON NL, 1993, INT J PEPT PROT RES, V42, P278
[9]  
Brown AR, 1998, SYNLETT, P817
[10]  
BROWN AR, 1999, CHEM REV, V99, P1549