The evolving role of diet in prostate cancer risk and progression

被引:53
作者
Kaiser, Adeel [1 ]
Haskins, Christopher [1 ]
Siddiqui, Mohummad M. [2 ,5 ]
Hussain, Arif [3 ,4 ,5 ]
D'Adamo, Christopher [6 ]
机构
[1] Univ Maryland, Sch Med, Dept Radiat Oncol, 22 S Greene St, Baltimore, MD 21201 USA
[2] Univ Maryland, Sch Med, Dept Surg, Div Urol, Baltimore, MD 21201 USA
[3] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA
[4] Univ Maryland, Greenebaum Comprehens Canc Ctr, Baltimore, MD 21201 USA
[5] Univ Maryland, Sch Med, Baltimore Vet Affairs Med Ctr, Baltimore, MD 21201 USA
[6] Univ Maryland, Sch Med, Dept Family & Community Med, Baltimore, MD 21201 USA
关键词
adipokines; diet; ketogenic; lycopene; metabolic syndrome; periprostatic fat; prostate cancer; DE-NOVO STEROIDOGENESIS; BODY-MASS INDEX; METABOLIC SYNDROME; LOW-CARBOHYDRATE; PHASE-II; CALORIC RESTRICTION; PANCREATIC-CANCER; C-PEPTIDE; INSULIN; LYCOPENE;
D O I
10.1097/CCO.0000000000000519
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose of review This overview examines the rationale for dietary interventions for prostate cancer by summarizing the current evidence base and biological mechanisms for the involvement of diet in disease incidence and progression. Recent findings Recent data have further solidified the association between insulin resistance and prostate cancer with the homeostatic model assessment of insulin resistance. Data also show that periprostatic adipocytes promote extracapsular extension of prostate cancer through chemokines, thereby providing a mechanistic explanation for the association observed between obesity and high-grade cancer. Regarding therapeutics, hyperinsulinemia may be the cause of resistance to phosphatidylinositol-3 kinase inhibitors in the treatment of prostate cancer, leading to new investigations combining these drugs with ketogenic diets. Summary Given the recently available data regarding insulin resistance and adipokine influence on prostate cancer, dietary strategies targeting metabolic syndrome, diabetes, and obesity should be further explored. In macronutrient-focused therapies, low carbohydrate/ketogenic diets should be favored in such interventions because of their superior impact on weight loss and metabolic parameters and encouraging clinical data. Micronutrients, including the carotenoid lycopene which is found in highest concentrations in tomatoes, may also play a role in prostate cancer prevention and prognosis through complementary metabolic mechanisms. The interplay between genetics, diet, and prostate cancer is an area of emerging focus that might help optimize therapeutic dietary response in the future through personalization.
引用
收藏
页码:222 / 229
页数:8
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