Hepatitis E virus infection in patients infected with human immunodeficiency virus in an endemic area in Iran

被引：14

作者：

Ramezani, Amitis ^{[1
]}

Velayati, Ali Akbar ^{[2
]}

Khorami-Sarvestani, Sara ^{[3
]}

Eslamifar, Ali ^{[1
]}

Mohraz, Minoo ^{[4
]}

Banifazl, Mohammad ^{[5
]}

Bidari-Zerehpoosh, Farahnaz ^{[6
]}

Yaghmaei, Farhad ^{[1
]}

McFarland, Willi ^{[7
]}

Foroughi, Maryam ^{[4
]}

Keyvani, Hossein ^{[8
]}

Mostafavi, Ehsan ^{[9
]}

Aghakhani, Arezoo ^{[1
]}

机构：

[1] Pasteur Inst Iran, Dept Clin Res, Tehran, Iran

[2] Masih Daneshvari Hosp, Tehran, Iran

[3] Hopegenerat Fdn, Tehran, Iran

[4] Iranian Res Ctr HIV AIDS, Tehran, Iran

[5] Iranian Soc Support Patients Infect Dis, Tehran, Iran

[6] Shahid Beheshti Univ Med Sci, Loghman Hosp, Dept Pathol, Tehran, Iran

[7] San Francisco Dept Publ Hlth, HIV Epidemiol Sect, San Francisco, CA USA

[8] Univ Tehran Med Sci, Dept Virol, Tehran, Iran

[9] Pasteur Inst Iran, Dept Epidemiol, Tehran, Iran

来源：

INTERNATIONAL JOURNAL OF STD & AIDS | 2013年 / 24卷 / 10期

关键词：

Hepatitis E virus; human immunodeficiency virus; chronic hepatitis E virus; Iran; HIV; AIDS; co-infection; hepatitis; CELL-CULTURE; HIV; POPULATION; SEROPREVALENCE; TRANSFUSION; PREVALENCE; ANTIBODIES;

D O I：

10.1177/0956462413484457

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Some studies have suggested that hepatitis E virus is more frequent in human immunodeficiency virus (HIV) patients and can progress to chronic infection. We aimed to determine the prevalence of hepatitis E virus antibodies and RNA in a series of 100 HIV-infected patients in Tehran, Iran, with comparison to 52 healthy HIV, hepatitis B and C-negative blood donors as controls. HIV-infected patients were also tested for hepatitis E virus-RNA. Among the HIV-infected patients, 10% had antibodies to hepatitis E virus - a finding not significantly different from the uninfected controls (11.5%). No HIV-infected patients had hepatitis E virus IgM antibodies nor did any have detectable hepatitis E virus-RNA. We found no associations between anti-hepatitis E virus IgG-seropositivity and age, sex, route of HIV acquisition, aminotransferases levels, CD4, antiretroviral therapy, hepatitis B virus and hepatitis C virus co-infection. Hepatitis E virus is relatively prevalent in our HIV-infected patients, although without evidence of chronic infection and no more common than among HIV-negative controls or the general population. For the present, we do not recommend routine screening for hepatitis E virus infection in HIV-infected patients in our moderately endemic region.

引用

页码：769 / 774

页数：6

共 38 条

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