Highly Oxygenated Triterpenoids from the Marine Red Alga Laurencia mariannensis (Rhodomelaceae)

被引：28

作者：

Ji, Nai-Yun ^{[1
,2
]}

Li, Xiao-Ming ^{[1
]}

Xie, Hua ^{[3
]}

Ding, Jian ^{[3
]}

Li, Ke ^{[1
,2
]}

Ding, Lan-Ping ^{[1
]}

Wang, Bin-Gui ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Drug Res, Inst Mat Med, Shanghai 201203, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2008年 / 91卷 / 10期

关键词：

D O I：

10.1002/hlca.200890207

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new and one known squalenoid-derived triterpenoids. namely, laurenmariannol (1) and (21 alpha)-21-hydroxythyrsiferol (2). and the known thyrsiferol (3) were isolated and identified from the marine red alga Laurencia mariannensis, which was collected off the coast of Hainan and Weizhou Islands of China. The structures of these compounds were established by means of spectroscopic analyses, as well as by comparison with literature data. Compounds I and 2 displayed significant cytotoxic activity against P-388 tumor cells with IC50 values of 0.6 and 6.6 mu g/ml, respectively.

引用

页码：1940 / 1946

页数：7

共 17 条

[1]

Blunt J.W., 1978, TETRAHEDRON LETT, V19, P69

[2] Highly brominated mono- and bis-phenols from the marine red alga Symphyocladia latiuscula with radical-scavenging activity [J].

Duan, Xiao-Juan ;

Li, Xiao-Ming ;

Wang, Bin-Gui .

JOURNAL OF NATURAL PRODUCTS, 2007, 70 (07) :1210-1213

[3] Evaluation of antioxidant property of extract and fractions obtained from a red alga, Polysiphonia urceolata [J].

Duan, XJ ;

Zhang, WW ;

Li, XM ;

Wang, BG .

FOOD CHEMISTRY, 2006, 95 (01) :37-43

[4] Marine polyether triterpenes [J].

Fernández, JJ ;

Souto, ML ;

Norte, M .

NATURAL PRODUCT REPORTS, 2000, 17 (03) :235-246

[5] Total synthesis of thyrsiferyl 23-acetate, a specific inhibitor of protein phosphatase 2A and an anti-leukemic inducer of apoptosis [J].

González, IC ;

Forsyth, CJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (38) :9099-9108

[6] Diterpenes, sesquiterpenes, and a C15-acetogenin from the marine red alga Laurencia mariannensis [J].

Ji, Nai-Yun ;

Li, Xiao-Ming ;

Li, Ke ;

Ding, Lan-Ping ;

Gloer, James B. ;

Wang, Bin-Gui .

JOURNAL OF NATURAL PRODUCTS, 2007, 70 (12) :1901-1905

[7] Laurendecumallenes A-B and laurendecumenynes A-B, halogenated nonterpenoid C15-Acetogenins from the marine red alga Laurencia decumbens [J].

Ji, Nai-Yun ;

Li, Xiao-Ming ;

Li, Ke ;

Wang, Bin-Gui .

JOURNAL OF NATURAL PRODUCTS, 2007, 70 (09) :1499-1502

[8] Terpenes and polybromoindoles from the marine red alga Laurencia decumbens (Rhodomelaceae) [J].

Ji, Nai-Yun ;

Li, Xiao-Ming ;

Cui, Chuan-Ming ;

Wang, Bin-Gui .

HELVETICA CHIMICA ACTA, 2007, 90 (09) :1731-1736

[9] Two new halogenated chamigrane-type sesquiterpenes and other secondary metabolites from the marine red alga Laurencia okamurai and their chemotaxonomic significance [J].

Ji, Nai-Yun ;

Li, Xiao-Ming ;

Zhang, Yi ;

Wang, Bin-Gui .

BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2007, 35 (09) :627-630

[10] Aristolane sesquiterpenes and highly brominated indoles from the marine red alga Laurencia similis (Rhodomelaceae) [J].

Ji, Nai-Yun ;

Li, Xiao-Ming ;

Ding, Lan-Ping ;

Wang, Bin-Gui .

HELVETICA CHIMICA ACTA, 2007, 90 (02) :385-391

← 1 2 →