Synthesis and application of new iminopyridine ligands to enantioselective copper(II)-catalyzed Henry reaction

被引：14

作者：

Solinas, Maurizio ^{[1
]}

Sechi, Barbara ^{[1
]}

Baldino, Salvatore ^{[2
]}

Chelucci, Giorgio ^{[2
]}

机构：

[1] UOS Sassari, Ist Chim Biomol, CNR, I-07100 Sassari, Italy

[2] Univ Sassari, Dipartimento Agr, I-07100 Sassari, Italy

来源：

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2013年 / 378卷

关键词：

Chiral iminopyridines; Enantioselective Henry reaction; Asymmetric catalysis; beta-Nitroalcohols; Copper(II)-catalysts; Cu(OAc)(2)center dot H2O; ASYMMETRIC NITROALDOL REACTIONS; SALEN-CHROMIUM COMPLEXES; FACILE SYNTHESIS; CATALYSTS; ALDEHYDES; AMINO; BIS(THIAZOLINE); BIS(OXAZOLINE); BENZALDEHYDE; DIETHYLZINC;

D O I：

10.1016/j.molcata.2013.06.008

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Chiral iminopyridines obtained by reaction between a variety of chiral amines and pyridyl aldehydes or ketones were assessed as catalysts in the enantioselective Henry reaction between nitromethane and 2-methoxybenzaldehyde in the presence of copper(II) acetate. 1-(2-Methoxyphenyl)-2-nitroethanol was obtained in moderate yields and good enantioselectivities (up to 82% ee) under straightforward experimental conditions without the need for air or moisture exclusion. The best enantioselectivity (82% ee) was obtained by an iminopyridine based on a camphane skeleton. (c) 2013 Elsevier B.V. All rights reserved.

引用

页码：206 / 212

页数：7

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