Hepatitis C Infection in the Elderly

被引：24
作者：
Saab, Sammy [1 ,2 ]
Rheem, Justin [3 ]
Sundaram, Vinay [4 ]
机构：
[1] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA
[2] Univ Calif Los Angeles, Dept Surg, Los Angeles, CA 90024 USA
[3] Univ Calif Los Angeles, Harbor Med Ctr, Dept Med, Torrance, CA 90509 USA
[4] Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USA
来源：
DIGESTIVE DISEASES AND SCIENCES | 2015年 / 60卷 / 11期
关键词：
Hepatitis C; Elderly; Antiviral therapy; Systematic review; RIBAVIRIN COMBINATION THERAPY; TRANSFUSION-ASSOCIATED HEPATITIS; PEGYLATED INTERFERON-ALPHA; VIRUS-INFECTION; UNITED-STATES; PLUS RIBAVIRIN; OLDER PATIENTS; CHRONIC HCV; GENOTYPE; HEPATOCELLULAR-CARCINOMA;
D O I：
10.1007/s10620-015-3717-6
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Hepatitis C virus (HCV) infection in the elderly population is a global medical burden and healthcare utilization concern. The majority of patients with hepatitis C in the USA are "baby boomers," who were born between 1945 and 1965. Consistently worldwide, HCV infection in elderly population is overrepresented and poses public health concerns. These individuals have been infected now for over two decades and are presenting with advanced liver disease. Traditionally, the use of pegylated interferon-based therapy has been limited in the elderly because of its adverse effects. The sustained virologic responses have also tended to be lower in the elderly than in younger adults. The emergence of non-interferon-based therapy with direct acting antiviral agents has expanded the pool of patients eligible for treatment. These agents have been found to be effective, tolerable, and safe in the elderly population.
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收藏
页码：3170 / 3180
页数：11
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