Structure and evolutionary origins of the CMG complex

被引：35

作者：

Onesti, Silvia ^{[1
]}

MacNeill, Stuart A. ^{[2
]}

机构：

[1] Elettra Sincrotrone Trieste, Area Sci Pk, Struct Biol Lab, I-34149 Trieste, Italy

[2] Univ St Andrews, St Andrews KY16 9ST, Fife, Scotland

来源：

CHROMOSOMA | 2013年 / 122卷 / 1-2期

关键词：

DNA replication; DNA helicase; CMG; MCM; GINS; Cdc45; EUKARYOTIC DNA-REPLICATION; HUMAN GINS COMPLEX; METHANOTHERMOBACTER-THERMAUTOTROPHICUS MCM; SINGLE-STRANDED-DNA; CRYSTAL-STRUCTURE; RECJ EXONUCLEASE; FUNCTIONAL INSIGHTS; HELICASE ACTIVITY; ESCHERICHIA-COLI; BUDDING YEAST;

D O I：

10.1007/s00412-013-0397-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The CMG (Cdc45-MCM-GINS) complex is the eukaryotic replicative helicase, the enzyme that unwinds double-stranded DNA at replication forks. All three components of the CMG complex are essential for its function, but only in the case of MCM, the molecular motor that harnesses the energy of ATP hydrolysis to catalyse strand separation, is that function clear. Here, we review current knowledge of the three-dimensional structure of the CMG complex and its components and highlight recent advances in our understanding of its evolutionary origins.

引用

页码：47 / 53

页数：7

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