New Flavonoids from Lysimachia christinae Hance

A chemical investigation of Lysimachia christinae, a traditional Chinese medicine used as an effective conservative treatment for gall stones, hepatolithiasis, and urinary calculi, resulted in the isolation of two new flavonoids, myricetin 3,3-di--L-rhamnopyranoside (1) and quercetin 3,3-di--L-rhamnopyranoside (2), along with the five known flavonoids quercetin 3-[O--L-rhamnopyranosyl-(12)--D-galactopyranoside], amentoflavone, hyperin, quercetin 3--D-glucopyranoside, and kaempferol 3--L-rhamnopyranoside. Amentoflavone was reported for the first time from the genus Lysimachia, and quercetin 3-[O--L-rhamopyranosyl-(12)--D-galactopyranoside] was isolated from this plant for the first time. The structures of the new compounds were elucidated on the basis of their chemical reactions and extensive spectroscopic analyses, including UV, mass, and NMR spectra.