Pathophysiology in endothelin-1 transgenic mice

被引：5
|
作者：
Theuring, F
Thöne-Reinecke, C
Vogler, H
Schmager, F
Rohmeiss, P
Slowinski, T
Neumayer, HH
Hocher, B
机构：
[1] Humboldt Univ, Univ Clin Charite, Berlin, Germany
[2] Free Univ Berlin, Inst Pharmacol & Toxicol, D-1000 Berlin, Germany
[3] Free Univ Berlin, Dept Nephrol, D-1000 Berlin, Germany
[4] Free Univ Berlin, Inst Mol Biol & Biochem, D-1000 Berlin, Germany
[5] Univ Heidelberg, Univ Clin Mannheim, Dept Nephrol, Heidelberg, Germany
[6] Schering Res Labs, Berlin, Germany
来源：
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1998年 / 31卷
关键词：
endothelin-1; renal hemodynamics; transgenic mouse model;
D O I：
10.1097/00005344-199800001-00140
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Transgenic mice expressing the human endothelin-1 (ET-1) were generated. These mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension. Consequently, a progressive decrease in renal blood flow and/or glomerular filtration rate was observed, demonstrated by altered creatinine clearance and by magnetic resonance imaging. These genetically altered transgenic mice provide an interesting animal model in which to elucidate the role of ET-1 in the modulation of renal hemodynamics and glomerular and tubule functions.
引用
收藏
页码：S489 / S491
页数：3
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