Effects of amphetamine, morphine, and CP 55, 940 on Go/No-Go task performance in rhesus monkeys

被引：4

作者：

Koek, Wouter ^{[1
,2
]}

Gerak, Lisa R. ^{[2
]}

France, Charles P. ^{[1
,2
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA

[2] Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA

来源：

BEHAVIOURAL PHARMACOLOGY | 2015年 / 26卷 / 05期

关键词：

amphetamine; CP; 55; 940; Go; No-Go task; impulsivity; morphine; rhesus monkeys; IMPULSIVITY; MICE;

D O I：

10.1097/FBP.0000000000000146

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

In humans, impulsivity measured as false alarms in a Go/No-Go task is reportedly decreased by amphetamine and is not affected by oxycodone and delta(9)-tetrahydrocannabinol. To model these findings in animals, three rhesus monkeys were trained to perform a food-reinforced Go/No-Go task. In this task, amphetamine was found to decrease false alarms (i.e. responding during No-Go trials), but only at doses that also decreased hits (i.e. responding during Go trials). Morphine generally decreased hits but not false alarms. The cannabinoid receptor agonist CP 55,940 decreased both false alarms and hits, but only at doses that also decreased the number of trials completed. Additional studies in animals and humans are necessary to delineate the conditions under which amphetamine and other psychoactive drugs affect impulsivity in Go/No-Go tasks.

引用

页码：481 / 484

页数：4

共 10 条

[1] Bupropion improves attention but does not affect impulsive behavior in healthy young adults [J].

Acheson, Ashley ;

de Wit, Harriet .

EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, 2008, 16 (02) :113-123

[2] The discriminative stimulus effects of midazolam are resistant to modulation by morphine, amphetamine, dizocilpine, and γ-butyrolactone in rhesus monkeys [J].

Bai, Xiang ;

France, Charles P. ;

Gerak, Lisa R. .

PSYCHOPHARMACOLOGY, 2011, 217 (04) :495-504

[3] Acute administration of d-amphetamine decreases impulsivity in healthy volunteers [J].

de Wit, H ;

Enggasser, JL ;

Richards, JB .

NEUROPSYCHOPHARMACOLOGY, 2002, 27 (05) :813-825

[4] Impulsivity as a determinant and consequence of drug use: a review of underlying processes [J].

de Wit, Harriet .

ADDICTION BIOLOGY, 2009, 14 (01) :22-31

[5] EFFECTS OF D-AMPHETAMINE AND MORPHINE ON DELAYED DISCRIMINATION - SIGNAL-DETECTION ANALYSIS AND ASSESSMENT OF RESPONSE REPETITION IN THE PERFORMANCE DEFICITS [J].

KOEK, W ;

SLANGEN, JL .

PSYCHOPHARMACOLOGY, 1984, 83 (04) :346-350

[6] Inhibitory control and response latency differences between C57BL/6J and DBA/2J mice in a Go/No-Go and 5-choice serial reaction time task and strain-specific responsivity to amphetamine [J].

Loos, Maarten ;

Staal, Jorn ;

Schoffelmeer, Anton N. M. ;

Smit, August B. ;

Spijker, Sabine ;

Pattij, Tommy .

BEHAVIOURAL BRAIN RESEARCH, 2010, 214 (02) :216-224

[7] Effects of THC on behavioral measures of impulsivity in humans [J].

McDonald, J ;

Schleifer, L ;

Richards, JB ;

de Wit, H .

NEUROPSYCHOPHARMACOLOGY, 2003, 28 (07) :1356-1365

[8] Behavioral inhibition in mice bred for high vs. low levels of methamphetamine consumption or sensitization [J].

Moschak, Travis M. ;

Stang, Katherine A. ;

Phillips, Tamara J. ;

Mitchell, Suzanne H. .

PSYCHOPHARMACOLOGY, 2012, 222 (02) :353-365

[9] ON THE CLASSIFICATION OF REINFORCEMENT SCHEDULES [J].

SCHOENFELD, WN ;

CUMMING, WW ;

HEARST, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1956, 42 (08) :563-570

[10] The prescription opioid, oxycodone, does not alter behavioral measures of impulsivity in healthy volunteers [J].

Zacny, James P. ;

de Wit, Harriet .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2009, 94 (01) :108-113

← 1 →