Pegylated Deoxycholic Acid Coated Gold Nanoparticles as a Highly Stable CT Contrast Agent

被引：7

作者：

Mohajeri, Mohammad ^{[1
]}

Iranpour, Pooya ^{[2
]}

Vahidi, Yasmin ^{[3
]}

Haghighi, Rezvan Ravanfar ^{[2
]}

Faghih, Zahra ^{[3
]}

Bararjanian, Morteza ^{[1
]}

Salehi, Peyman ^{[1
]}

机构：

[1] Shahid Beheshti Univ, Med Plants & Drugs Res Inst, Dept Phytochem, Via GC, Tehran, Iran

[2] Shiraz Univ Med Sci, Med Imaging Res Ctr, Shiraz, Iran

[3] Shiraz Univ Med Sci, Shiraz Inst Canc Res, Sch Med, Shiraz, Iran

来源：

CHEMISTRYSELECT | 2020年 / 5卷 / 29期

关键词：

Computed Tomography; Deoxycholic acid; Drug design; Gold Nanoparticles; Imaging agents; COMPUTED-TOMOGRAPHY; CANCER; CELLS; PARTICLES; TOXICITY; GROWTH;

D O I：

10.1002/slct.202001634

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The present study has been dedicated to the synthesis of a new and highly stable computed tomography contrast agent based on pegylated deoxycholic acid- coated gold nanoparticles (DCA-PEG-GNPs) measuring 17 nm in size. To stabilize the gold nanoparticles (GNPs) as well as increasing their vascular retention time, polyethylene glycol, PEG, with a molecular weight of 4 KD, was applied. Besides, for target delivery, deoxycholic acid (DCA) as a biologically active compound and a secondary bile acid, capable of interfering with some cancers, were selected. The bile acid was attached to the nanoparticle's surface with a polyethylene glycol (MW=1 KD) linker via an etherification reaction. Finally, the activity of the prepared compound was studied by means of a clinical CT instrument at various KVp values. The gained results depicted a very high activity of the compound to attenuate X-rays along with making contrast enhancement, even better than those of Visipaque as a commercial contrast agent. In addition, the DCA-PEG-GNPs displayed remarkable stability in a wide range of pHs,i. e. 2.5-11, and in different temperature conditions, ranging between -78 degrees C to 48 degrees C.

引用

页码：9119 / 9126

页数：8

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