99mTc-(Me)FGCDEVD, a potential tracer for apoptosis detection

被引：4

作者：

Bohn, Pierre ^{[1
,2
]}

Mouchard, Florian ^{[2
]}

Rouvet, Jean ^{[1
]}

de Boisgrollier, Anne-Caroline ^{[1
]}

Vera, Pierre ^{[1
,2
]}

机构：

[1] Ctr Henri Becquerel, Dept Nucl Med, F-76038 Rouen, France

[2] Univ Rouen, Fac Med & Pharm, Lab QuantIF LITIS EA4108, F-76000 Rouen, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 05期

关键词：

Apoptosis; Caspase-3; Technetium-99m; Tumor; Diagnosis agents;

D O I：

10.1016/j.bmcl.2012.12.088

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(Me)FGC(Bz)DEVD was radiolabeled with technetium-99m in high yield. This tracer was preferentially accumulated in apoptotic cells in the in vitro studies. Tumor uptake occurred in vivo after cisplatin injection due to the apoptosis induction, which not observed in the untreated tumors. Therefore, Tc-99m-(Me)FGCDEVD is a potential tracer for apoptosis detection. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1375 / 1378

页数：4

共 10 条

[1] Kit formulation for 99mTc-labeling of recombinant anti-HER2 Affibody molecules with a C-terminally engineered cysteine [J].

Ahlgren, Sara ;

Andersson, Kristofer ;

Tolmachev, Vladimir .

NUCLEAR MEDICINE AND BIOLOGY, 2010, 37 (05) :539-546

[2] Bombesin derivative radiolabeled with technetium-99m as agent for tumor identification [J].

Branco de Barros, Andre Luis ;

Mota, Luciene das Gracas ;

Ferreira, Carolina de Aguiar ;

de Oliveira, Monica Cristina ;

de Goes, Alfredo Miranda ;

Cardoso, Valbert Nascimento .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (21) :6182-6184

[3] APOPTOSIS - BASIC BIOLOGICAL PHENOMENON WITH WIDE-RANGING IMPLICATIONS IN TISSUE KINETICS [J].

KERR, JFR ;

WYLLIE, AH ;

CURRIE, AR .

BRITISH JOURNAL OF CANCER, 1972, 26 (04) :239-+

[4] Synthesis and evaluation of a novel 99mTc-labeled bioreductive probe for tumor hypoxia imaging [J].

Kimura, Sadaaki ;

Umeda, Izumi O. ;

Moriyama, Noriyuki ;

Fujii, Hirofumi .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (24) :7359-7362

[5] Apoptosis Imaging: Beyond Annexin V [J].

Niu, Gang ;

Chen, Xiaoyuan .

JOURNAL OF NUCLEAR MEDICINE, 2010, 51 (11) :1659-1662

[6] Small-Molecule Biomarkers for Clinical PET Imaging of Apoptosis [J].

Reshef, Ayelet ;

Shirvan, Anat ;

Akselrod-Ballin, Ayelet ;

Wall, Anders ;

Ziv, Ilan .

JOURNAL OF NUCLEAR MEDICINE, 2010, 51 (06) :837-840

[7]

Schutters K., 2010, APOPTOSIS, V1072, P15

[8] ABCC5, ERCC2, XPA and XRCC1 transcript abundance levels correlate with cisplatin chemoresistance in non-small cell lung cancer cell lines [J].

Weaver, David A. ;

Crawford, Erin L. ;

Warner, Kristy A. ;

Elkhairi, Fadel ;

Khuder, Sadik A. ;

Willey, James C. .

MOLECULAR CANCER, 2005, 4 (1)

[9] Apoptosis and Beyond: Cytometry in Studies of Programmed Cell Death [J].

Wlodkowic, Donald ;

Telford, William ;

Skommer, Joanna ;

Darzynkiewicz, Zbigniew .

RECENT ADVANCES IN CYTOMETRY, PART B: ADVANCES IN APPLICATIONS, FIFTH EDITION, 2011, 103 :55-98

[10]

Zhang Peilin, 2003, Mol Cancer, V2, P1

← 1 →