Acylation of Arylamines with Triethylamine Derivatives in Combination with tert-Butyl Hydroperoxide

被引：5

作者：

Chen, Cui ^{[1
]}

Liu, Weibing. ^{[1
]}

Liu, Bifu. ^{[2
]}

Zhou, Peng ^{[1
]}

Tan, Hua ^{[1
]}

机构：

[1] Guangdong Univ Petrochem Technol, Coll Chem, 2 Guandu Rd, Maoming 525000, Peoples R China

[2] Huizhou Univ, Sch Chem & Mat Engn, Huizhou 516007, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 8卷 / 04期

基金：

中国国家自然科学基金;

关键词：

alkyl transfer; N-dealkylation; N-acylation; trialkyl amines; C-N BOND; AMIDE; ALCOHOLS; ANNULATION; ALDEHYDES; CATALYST; PEPTIDE; ACCESS;

D O I：

10.1002/ajoc.201900119

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-acylation of arylamines with di- and trialkyl amines has been reported. This approach provides a general synthesis of aromatic amides by an alkyl transfer through cleavage of the C-N bond, and acts as a model for N-dealkylations and N-acylations. Additionally, the synthesis is a promising method towards amidation reactions, wherein di- and trialkyl amine derivatives are employed as sources of acyl carbon atoms and tert-butyl hydroperoxide is employed as the oxygen source of the acyl group.

引用

页码：470 / 474

页数：5

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