Genetics/Genomics/Proteomics of Gastric Adenocarcinoma

被引：11

作者：

Uppal, Dushant S. ^{[1
]}

Powell, Steven M. ^{[1
]}

机构：

[1] Univ Virginia, Div Gastroenterol Hepatol, Dept Med, Charlottesville, VA 22908 USA

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2013年 / 42卷 / 02期

关键词：

Gastric cancer; Molecular genetics; Hereditary gastric cancer; Genomics; Proteomics; E-CADHERIN MUTATIONS; FACTOR-KAPPA-B; GROWTH-FACTOR; INTESTINAL-TYPE; GERMLINE MUTATIONS; SOMATIC MUTATIONS; TUMOR-SUPPRESSOR; MICROSATELLITE INSTABILITY; PROTEOMIC IDENTIFICATION; GASTROINTESTINAL CANCER;

D O I：

10.1016/j.gtc.2013.01.005

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hereditary diffuse gastric cancer can be caused by epithelial cadherin mutations for which genetic testing is available. Inherited cancer predisposition syndromes including Lynch, Li-Fraumeni, and Peutz-Jeghers syndromes, can be associated with gastric cancer. Chromosomal and microsatellite instability occur in gastric cancers. Several consistent genetic and molecular alterations including chromosomal instability, microsatellite instability, and epigenetic alterations have been identified in gastric cancers. Biomarkers and molecular profiles are being discovered with potential for diagnostic, prognostic, and treatment guidance implications.

引用

页码：241 / +

页数：21

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