Biology of claudins

被引：274

作者：

Angelow, Susanne ^{[1
]}

Ahlstrom, Robert ^{[2
]}

Yu, Alan S. L. ^{[1
,2
]}

机构：

[1] Univ So Calif, Keck Sch Med, Div Nephrol, Dept Med, Los Angeles, CA 90089 USA

[2] Univ So Calif, Keck Sch Med, Dept Physiol & Biophys, Los Angeles, CA 90089 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 2008年 / 295卷 / 04期

关键词：

tight junction; paracellular; permeability;

D O I：

10.1152/ajprenal.90264.2008

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Claudins are a family of tight junction membrane proteins that regulate paracellular permeability of epithelia, likely by forming the lining of the paracellular pore. Claudins are expressed throughout the renal tubule, and mutations in two claudin genes are now known to cause familial hypercalciuric hypomagnesemia with nephrocalcinosis. In this review, we discuss recent advances in our understanding of the physiological role of various claudins in normal kidney function, and in understanding the fundamental biology of claudins, including the molecular basis for selectivity of permeation, claudin interactions in tight junction formation, and regulation of claudins by protein kinases and other intracellular signals.

引用

页码：F867 / F876

页数：10

共 118 条

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