Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care

被引：594

作者：

Chung, Ha Uk ^{[1
,2
]}

Kim, Bong Hoon ^{[1
,3
,4
,5
]}

Lee, Jong Yoon ^{[4
,6
]}

Lee, Jungyup ^{[4
]}

Xie, Zhaoqian ^{[3
,7
,8
]}

Ibler, Erin M. ^{[9
,10
]}

Lee, KunHyuck ^{[1
,3
]}

Banks, Anthony ^{[1
,4
,5
,11
]}

Jeong, Ji Yoon ^{[4
]}

Kim, Jongwon ^{[3
,12
]}

Ogle, Christopher ^{[1
,5
]}

Grande, Dominic ^{[4
,6
]}

Yu, Yongjoon ^{[4
]}

Jang, Hokyung ^{[4
]}

Assem, Pourya ^{[6
]}

Ryu, Dennis ^{[1
,5
]}

Kwak, Jean Won ^{[1
,8
]}

Namkoong, Myeong ^{[1
,13
]}

Park, Jun Bin ^{[4
]}

Lee, Yechan ^{[4
]}

Kim, Do Hoon ^{[4
]}

Ryu, Arin ^{[4
]}

Jeong, Jaeseok ^{[4
]}

You, Kevin ^{[4
]}

Ji, Bowen ^{[3
,7
,8
,14
]}

Liu, Zhuangjian ^{[15
]}

Huo, Qingze ^{[3
,7
,8
]}

Feng, Xue ^{[16
]}

Deng, Yujun ^{[7
,17
]}

Xu, Yeshou ^{[7
,18
]}

Jang, Kyung-In ^{[19
]}

Kim, Jeonghyun ^{[20
]}

Zhang, Yihui ^{[16
]}

Ghaffari, Roozbeh ^{[1
,5
,13
]}

Rand, Casey M. ^{[10
,21
]}

Schau, Molly ^{[22
]}

Hamvas, Aaron ^{[21
,22
,23
]}

Weese-Mayer, Debra E. ^{[10
,21
,23
]}

Huang, Yonggang ^{[3
,5
,7
,8
]}

Lee, Seung Min ^{[24
]}

Lee, Chi Hwan ^{[25
,26
]}

Shanbhag, Naresh R. ^{[6
]}

Paller, Amy S. ^{[5
,9
,23
]}

Xu, Shuai ^{[1
,5
,9
]}

Rogers, John A. ^{[1
,3
,4
,5
,8
,13
,27
,28
]}

机构：

[1] Northwestern Univ, Simpson Querrey Inst, Chicago, IL 60611 USA

[2] Northwestern Univ, Dept Elect Engn & Comp Sci, Evanston, IL 60208 USA

[3] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA

[4] Univ Illinois, Frederick Seitz Mat Res Lab, Urbana, IL 61801 USA

[5] Northwestern Univ, Ctr Biointegrated Elect, Evanston, IL 60208 USA

[6] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA

[7] Northwestern Univ, Dept Civil & Environm Engn, Evanston, IL 60208 USA

[8] Northwestern Univ, Dept Mech Engn, Evanston, IL 60208 USA

[9] Northwestern Univ, Dept Dermatol, Feinberg Sch Med, Chicago, IL 60611 USA

[10] Ann & Robert H Lurie Childrens Hosp Chicago, Ctr Auton Med, Dept Pediat, Chicago, IL 60611 USA

[11] Univ Illinois, Loomis Lab Phys, Urbana, IL 61801 USA

[12] Kyung Hee Univ, Dept Mech Engn, Yongin 17104, South Korea

[13] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

[14] Shanghai Jiao Tong Univ, Dept Micro Nano Elect, Shanghai 200240, Peoples R China

[15] ASTAR, Inst High Performance Comp, Singapore 138632, Singapore

[16] Tsinghua Univ, Appl Mech Lab, Dept Engn Mech, Ctr Mech & Mat,Ctr Flexible Elect Technol, Beijing 100084, Peoples R China

[17] Shanghai Jiao Tong Univ, State Key Lab Mech Syst & Vibrat, Shanghai 200240, Peoples R China

[18] Southeast Univ, Key Lab C&PC Struct, Minist Educ, Nanjing 2100096, Jiangsu, Peoples R China

[19] Daegu Gyeongbuk Inst Sci & Technol, Dept Robot Engn, Daegu 42988, South Korea

[20] Kwangwoon Univ, Dept Elect Convergence Engn, Seoul 01897, South Korea

[21] Ann & Robert H Lurie Childrens Hosp Chicago, Stanley Manne Childrens Res Inst, Chicago, IL 60611 USA

[22] Ann & Robert H Lurie Childrens Hosp Chicago, Div Neonatol, Dept Pediat, Chicago, IL 60611 USA

[23] Ann & Robert H Lurie Childrens Hosp Chicago, Dept Pediat, Chicago, IL 60611 USA

[24] Kookmin Univ, Dept Energy Elect Convergence, Seoul 02707, South Korea

[25] Purdue Univ, Sch Mech Engn, Weldon Sch Biomed Engn, Ctr Implantable Devices, W Lafayette, IN 47907 USA

[26] Purdue Univ, Birck Nanotechnol Ctr, W Lafayette, IN 47907 USA

[27] Northwestern Univ, Dept Chem, 2145 Sheridan Rd, Evanston, IL 60208 USA

[28] Northwestern Univ, Feinberg Sch Med, Dept Neurol Surg, Chicago, IL 60611 USA

来源：

SCIENCE | 2019年 / 363卷 / 6430期

基金：

中国国家自然科学基金; 比尔及梅琳达.盖茨基金会;

关键词：

PULSE TRANSIT-TIME; BLOOD-PRESSURE CHANGES; ARRIVAL-TIME; INFANTS;

D O I：

10.1126/science.aau0780

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Existing vital signmonitoring systems in the neonatal intensive care unit (NICU) requiremultiple wires connected to rigid sensors with strongly adherent interfaces to the skin. We introduce a pair of ultrathin, soft, skin-like electronic devices whose coordinated, wireless operation reproduces the functionality of these traditional technologies but bypasses their intrinsic limitations. The enabling advances in engineering science include designs that support wireless, battery-free operation; real-time, in-sensor data analytics; time-synchronized, continuous data streaming; soft mechanics and gentle adhesive interfaces to the skin; and compatibility with visual inspection and with medical imaging techniques used in the NICU. Preliminary studies on neonates admitted to operating NICUs demonstrate performance comparable to the most advanced clinical-standard monitoring systems.

引用

页码：947 / +

页数：77

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