Cancer immunotherapy Re-programming cells of the innate and adaptive immune systems

被引：9

作者：

Manjili, Masoud H. ^{[1
]}

Payne, Kyle K. ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Dept Microbiol & Immunol, Massey Canc Ctr, Richmond, VA 23298 USA

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 02期

关键词：

NKT cells; immunotherapy; myeloid-derived suppressor cells; adoptive cellular therapy; common gamma chain cytokines; breast cancer; TUMOR-SENSITIZED LYMPHOCYTES; ACTIVATED NKT CELLS; CD8(+) T-CELLS; SUPPRESSOR-CELLS; DENDRITIC CELLS; IMMUNOREGULATORY AXIS; ANTINEOPLASTIC AGENT; PROGNOSTIC-FACTOR; BREAST-CANCER; IFN-GAMMA;

D O I：

10.4161/onci.1.2.18113

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancers utilize multiple mechanisms to overcome immune responses. Emerging evidence suggest that immunotherapy of cancer should focus on inducing and re-programming cells of the innate and adaptive immune systems rather than focusing solely on T cells. Recently, we have shown that such a multifaceted approach can improve immunotherapy of breast cancer.

引用

页码：201 / 204

页数：4

共 28 条

[1] Bryostatin-1, a Naturally Occurring Antineoplastic Agent, Acts as a Toll-like Receptor 4 (TLR-4) Ligand and Induces Unique Cytokines and Chemokines in Dendritic Cells [J].

Ariza, Maria Eugenia ;

Ramakrishnan, Rupal ;

Singh, Narendra P. ;

Chauhan, Ashok ;

Nagarkatti, Prakash S. ;

Nagarkatti, Mitzi .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (01) :24-34

[2] A novel immunoregulatory axis of NKT cell subsets regulating tumor immunity [J].

Berzofsky, Jay A. ;

Terabe, Masaki .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2008, 57 (11) :1679-1683

[3] NKT cells in tumor immunity: Opposing subsets define a new immunoregulatory axis [J].

Berzofsky, Jay A. ;

Terabe, Masaki .

JOURNAL OF IMMUNOLOGY, 2008, 180 (06) :3627-3635

[4] Bryostatin 1/ionomycin (B/I) ex vivo stimulation preferentially activates L-selectinlow tumor-sensitized lymphocytes [J].

Chin, CS ;

Miller, CHT ;

Graham, L ;

Parviz, M ;

Zacur, S ;

Patel, B ;

Duong, A ;

Bear, HD .

INTERNATIONAL IMMUNOLOGY, 2004, 16 (09) :1283-1294

[5] IL-2 receptor γ chain cytokines differentially regulate human CD8+CD127+ and CD8+CD127- T cell division and susceptibility to apoptosis [J].

Crawley, Angela M. ;

Katz, Tanya ;

Parato, Karl ;

Angel, Jonathan B. .

INTERNATIONAL IMMUNOLOGY, 2009, 21 (01) :29-42

[6] Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4+ and CD8+ T cell responses in humans [J].

Davis, ID ;

Chen, WS ;

Jackson, H ;

Parente, P ;

Shackleton, M ;

Hopkins, W ;

Chen, QY ;

Dimopoulos, N ;

Luke, T ;

Murphy, R ;

Scott, AM ;

Maraskovsky, E ;

McArthur, G ;

MacGregor, D ;

Sturrock, S ;

Tai, TY ;

Green, S ;

Cuthbertson, A ;

Maher, D ;

Miloradovic, L ;

Mitchell, SV ;

Ritter, G ;

Jungbluth, AA ;

Chen, YT ;

Gnjatic, S ;

Hoffman, EW ;

Old, LJ ;

Cebon, JS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (29) :10697-10702

[7] Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy [J].

Diaz-Montero, C. Marcela ;

Salem, Mohamed Labib ;

Nishimura, Michael I. ;

Garrett-Mayer, Elizabeth ;

Cole, David J. ;

Montero, Alberto J. .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2009, 58 (01) :49-59

[8] Adoptive transfer of bryostatin-activated tumor-sensitized lymphocytes prevents or destroys tumor metastases without expansion in vitro [J].

Fleming, MD ;

Bear, HD ;

Lipshy, K ;

Kostuchenko, PJ ;

Portocarero, D ;

McFadden, AWJ ;

Barrett, SK .

JOURNAL OF IMMUNOTHERAPY, 1995, 18 (03) :147-155

[9] Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13 [J].

Gabitass, Rachel F. ;

Annels, Nicola E. ;

Stocken, Deborah D. ;

Pandha, Hardev A. ;

Middleton, Gary W. .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2011, 60 (10) :1419-1430

[10] The antineoplastic agent bryostatin-1 differentially regulates IFN-γ receptor Subunits in monocytic cells:: Transcriptional and posttranscriptional control of IFN-γR2 [J].

Garcia, Carmen S. ;

Curiel, Rafael E. ;

Mwatibo, James M. ;

Pestka, Sidney ;

Li, Huifen ;

Espinoza-Delgado, Igor .

JOURNAL OF IMMUNOLOGY, 2006, 177 (04) :2707-2716

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