Cancer immunotherapy Re-programming cells of the innate and adaptive immune systems

被引:9
作者
Manjili, Masoud H. [1 ]
Payne, Kyle K. [1 ]
机构
[1] Virginia Commonwealth Univ, Dept Microbiol & Immunol, Massey Canc Ctr, Richmond, VA 23298 USA
关键词
NKT cells; immunotherapy; myeloid-derived suppressor cells; adoptive cellular therapy; common gamma chain cytokines; breast cancer; TUMOR-SENSITIZED LYMPHOCYTES; ACTIVATED NKT CELLS; CD8(+) T-CELLS; SUPPRESSOR-CELLS; DENDRITIC CELLS; IMMUNOREGULATORY AXIS; ANTINEOPLASTIC AGENT; PROGNOSTIC-FACTOR; BREAST-CANCER; IFN-GAMMA;
D O I
10.4161/onci.1.2.18113
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cancers utilize multiple mechanisms to overcome immune responses. Emerging evidence suggest that immunotherapy of cancer should focus on inducing and re-programming cells of the innate and adaptive immune systems rather than focusing solely on T cells. Recently, we have shown that such a multifaceted approach can improve immunotherapy of breast cancer.
引用
收藏
页码:201 / 204
页数:4
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