Gene targeting in Aspergillus fumigatus by homologous recombination is facilitated in a nonhomologous end-joining-deficient genetic background

被引：218

作者：

Krappmann, S ^{[1
]}

Sasse, C ^{[1
]}

Braus, GH ^{[1
]}

机构：

[1] Univ Gottingen, Inst Microbiol & Genet, Dept Microbiol & Mol Genet, D-37077 Gottingen, Germany

来源：

EUKARYOTIC CELL | 2006年 / 5卷 / 01期

关键词：

D O I：

10.1128/EC.5.1.212-215.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The akuA gene encoding the Ku70 component of the nonhomologous end-joining machinery was deleted in the opportunistic pathogen Aspergillus fumigatus. No obvious phenotype could be assessed for the corresponding mutant strain but relative frequencies of homologous recombination were increased as deduced from targeting the laccase-encoding abr2 gene.

引用

页码：212 / 215

页数：4

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