Anti-inflammatory, Anti-Angiogenic and Anti-Nociceptive Activities of 4-Hydroxybenzaldehyde

被引：18
作者：
Lim, Eun-Ju [1 ]
Kang, Hyun-Jung [2 ,3 ]
Jung, Hyun-Joo [1 ]
Kim, Kyunghoon
Lim, Chang-Jin [2 ,3 ]
Park, Eun-Hee [1 ]
机构：
[1] Sookmyung Womens Univ, Coll Pharm, Seoul 150742, South Korea
[2] Kangwon Natl Univ, Div Life Sci, Chunchon 200701, South Korea
[3] Kangwon Natl Univ, Life Sci Res Inst, Chunchon 200701, South Korea
来源：
BIOMOLECULES & THERAPEUTICS | 2008年 / 16卷 / 03期
关键词：
Anti-angiogenic; Anti-inflammatory; Anti-nociceptive; Cyclooxygenase-2; 4-hydroxybenzaldehyde; Inducible nitric oxide synthase; Nitric oxide; RAW264.7; Reactive oxygen species;
D O I：
10.4062/biomolther.2008.16.3.231
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The current work was designed to assess novel pharmacological activities of 4-hydroxybenzaldehyde (HD), a major phenolic constituent of various natural products of plant origin, such as Gastrodia elata Blume. HID exhibited a significant inhibition in the chick chorioallantoic membrane (CAM) angiogenesis. HD also displayed an inhibitory effect in acetic acid-induced permeability in mice. Anti-nociceptive activity of HD was convinced using the acetic acid-induced writhing test in mice. HD was able to suppress production of nitric oxide (NO) and induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the lipopolysaccharide (LPS)-activated RAW264.7 macrophages. HD also diminished the reactive oxygen species (ROS) level elevated in the LPS-activated macrophages. In brief, HD exhibits anti-angiogenic, anti-inflammatory and anti-nociceptive activities possibly via down-regulating iNOS and/or COX-2, which may be partly responsible for pharmacological efficacies of various natural products.
引用
收藏
页码：231 / 236
页数：6
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