Synthesis and molecular-weight characteristics of n-vinylpyrrolidone and 2-methyl-5-vinylpyridine copolymers

被引：3

作者：

Kedik, S. A. ^{[1
]}

Panov, A. V. ^{[1
]}

Sakaeva, I. V. ^{[2
]}

Kochkina , Yu V. ^{[2
]}

Eremin, D. V. ^{[1
]}

Suslov, V. V. ^{[1
]}

机构：

[1] Inst Pharmaceut Technol, Moscow, Russia

[2] Minist Publ Hlth Russian Federat, State Sci Ctr Drug Expertise & Control, Moscow, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2012年 / 46卷 / 08期

关键词：

copolymer synthesis; N-vinylpyrrolidone; 2-methyl-5-vinylpyridine;

D O I：

10.1007/s11094-012-0829-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N-Vinylpyrrolidone and 2-methyl-5-vinylpyridine copolymers with various ratios of monomer units and molecular weights were synthesized by radical copolymerization using an injection method. The ratio of monomer units was determined by non-aqueous potentiometric titration and C-13 NMR methods. The viscosity-average molecular weights of copolymers containing 35 - 39 mol% of 2-methyl-5-vinylpyridine were in the range 15.2 - 27.6 kDa. Copolymers with 2-methyl-5-vinylpyridine content up to 75 +/- 5 mol% exhibited good solubility in water.

引用

页码：478 / 481

页数：4

共 36 条

[1] Synthesis and molecular-weight characteristics of n-vinylpyrrolidone and 2-methyl-5-vinylpyridine copolymers
S. A. Kedik
A. V. Panov
I. V. Sakaeva
Yu. V. Kochkina(Cherta)
D. V. Eremin
V. V. Suslov
Pharmaceutical Chemistry Journal, 2012, 46 : 478 - 481
[2] Synthesis and Molecular-Weight Characteristics of N-Oxidized Copolymers of N-Vinylpyrrolidone and 2-Methyl-5-Vinylpyridine
Vorfolomeeva, E. V.
Kedik, S. A.
Panov, A. V.
Zhavoronok, E. S.
Efimov, Yu. S.
Starchenkova, M. S.
Vasil'eva, D. V.
Zatonskii, G. V.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2015, 49 (08) : 554 - 558
[3] Influence of various factors on the solubility of N-vinylpyrrolidone and 2-methyl-5-vinylpyridine copolymers in water
Kedik, S. A.
Panov, A. V.
Suslov, V. V.
Eremin, D. V.
Ivanova, T. E.
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Malinovskaya, G. O.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2013, 47 (06) : 318 - 320
[4] MODIFICATION OF THE ANTITUMOR ACTION OF CYTOSTATIC DRUGS USING A COPOLYMER OF N-VINYLPYRROLIDONE AND 2-METHYL-5-VINYLPYRIDINE
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Kochkina, Yu. V.
Yartsev, E. I.
Eremin, D. V.
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PHARMACEUTICAL CHEMISTRY JOURNAL, 2017, 51 (07) : 523 - 527
[5] Modification of the Antitumor Action of Cytostatic Drugs Using a Copolymer of N-Vinylpyrrolidone and 2-Methyl-5-Vinylpyridine
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E. I. Yartsev
D. V. Eremin
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Pharmaceutical Chemistry Journal, 2017, 51 : 523 - 527
[6] Synthesis and radioprotector activity of N-vinylpyrrolidone and 2-methyl-5-vinyltetrazole copolymers
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[7] Effect of Synthesis Conditions on Molecular Characteristics of Coumarin and N-Vinylpyrrolidone Copolymers
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[10] Synthesis of N-vinylpyrrolidone copolymers with 2-aminoethyl methacrylate as drug carriers
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