Multicomponent synthesis of polysubstituted dihydroquinoline derivatives

被引：18
作者：
Yu, Yan
Tu, Man-Su
Jiang, Bo [1 ]
Wang, Shu-Liang
Tu, Shu-Jiang
机构：
[1] Jiangsu Normal Univ, Sch Chem & Chem Engn, Xuzhou 211116, Peoples R China
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 38期
基金：
美国国家科学基金会;
关键词：
Microwave (MW)-assisted synthesis; Polysubstituted hydroquinoline; Multicomponent domino reactions; DOMINO REACTION; EFFICIENT SYNTHESIS; AROMATIC-AMINES; GLYCINE-SITE; WATER; QUINOLINES; REARRANGEMENT; ANILINES; ACCESS; AGENTS;
D O I：
10.1016/j.tetlet.2012.07.008
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of new poly-functionalized dihydroquinoline derivatives (26 examples) were synthesized via three-component reactions of aldehydes (1 equiv) and 1-arylethylidenemalononitriles (2 equiv) in ethylene glycol using NaOH as a base promoter under microwave irradiation. During these reaction processes, the domino construction of dihydroquinoline skeleton with concomitant formation of two new cycles was readily achieved in a one-pot operation and in an intermolecular manner. (C) 2012 Elsevier Ltd. All rights reserved.
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收藏
页码：5071 / 5075
页数：5
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