One-Pot Synthesis of 3-Cyano-2-pyridones

被引：9

作者：

Wang, Yingcai ^{[1
]}

Liu, Gang ^{[1
]}

Reyes, Jeremy Chris P. ^{[1
]}

Duverna, Randolph ^{[1
]}

机构：

[1] Amgen Inc, Dept Therapeut Discovery, San Francisco, CA 94080 USA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2015年 / 52卷 / 04期

关键词：

GOLD-CATALYZED CYCLOISOMERIZATION; BIOLOGICAL EVALUATION; CARDIOTONIC AGENTS; DERIVATIVES; 2-PYRIDONES; CYCLOADDITION; EFFICIENT; CONDENSATION; ISOCYANATES; PYRIDONES;

D O I：

10.1002/jhet.2227

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile synthesis of 3-cyano-2-pyridones via a one-pot, four-component condensation of ethyl cyanoacetate, ketones, aldehydes, and ammonium acetate under very mild conditions has been developed. This method provides rapid access to this type of valuable heterocyclic compounds from readily available materials in a single operation.

引用

页码：1185 / 1191

页数：7

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