A Study on the Biological Activity of 2-thioxo-imidazolidin-4-ones

被引：23

作者：

Vengurlekar, Sudha ^{[1
]}

Sharma, Rajesh ^{[1
]}

Trivedi, Piyush ^{[2
]}

机构：

[1] Devi Ahilya Vishwavidyalaya, Sch Pharm, Indore 452017, Madhya Pradesh, India

[2] Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, MP, India

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2012年 / 9卷 / 05期

关键词：

2-Thioxo-imidazolidin-4-one; solid phase synthesis; spectral studies; biological activities; 2-Thiohydantoin; UNSATURATED HYDANTOIN DERIVATIVES; NEUTRAL MOLECULES; AMINO-ACIDS; 2-THIOHYDANTOINS; THIOHYDANTOINS; ANTIBACTERIAL; INHIBITORS; DISCOVERY; BEARING;

D O I：

10.2174/157018012800389322

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The broad and potent activity of 2-thioxo-imidazolidin-4-one (2-thiohydantoin) has established it as one of the biologically important scaffolds. This article highlights the medicinal chemistry investigations in search for novel 2-thioxo-imidazolidin-4-one derivatives with promising biological activities. New 2-thioxo-imidazolidin-4-one derivatives contain diaryl, triaryl, pyrimidine, cycloalkylamines and glucopyranosyl substituents and their aryl and halogen and alkyl derivatives, and other substituent with varied the monocyclic (thiadiazole, sulfadiazole) heterocycles linked directly or through alkyl chain with the imidazolidine nucleus. Recently obtained 2-thioxo-imidazolidin-4-one derivatives exhibit promising antibacterial, antifungal, anticancer, anti-inflammatory and many more biological activities. This review shows current tendency in the 2-thioxo-imidazolidin-4-one synthesis and reveals the 2-thioxo-imidazolidin-4-one core to be potent pharmacophoric moiety.

引用

页码：549 / 555

页数：7

共 61 条

[1] 5-substituted-2-thiohydantoin analogs as a novel class of antitumor agents [J].

AlObaid, AM ;

ElSubbagh, HI ;

Khodair, AI ;

Elmazar, MMA .

ANTI-CANCER DRUGS, 1996, 7 (08) :873-880

[2] SOME 5-(OXOALKYL)-2-THIOHYDANTOINS AND THEIR DERIVATIVES [J].

ARCHER, S ;

UNSER, MJ ;

FROELICH, E .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1956, 78 (23) :6182-6185

[3] Synthesis and Antimicrobial Activity of New Tetrahydro-Naphthalene-Thiazolidinedione and Thiohydantoine Derivatives [J].

Ates-Alagoz, Zeynep ;

Altanlar, Nurten ;

Buyukbingol, Erdem .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2009, 46 (06) :1375-1379

[4] SYNTHESIS AND IMMUNOMODULATING ACTIVITY OF 1-AMINO-2-THIOHYDANTOIN DERIVATIVES [J].

BLANC, M ;

CUSSAC, M ;

BOUCHERLE, A ;

LECLERC, G .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1992, 27 (08) :839-843

[5] Structure and anti-proliferation function of 5,5-diphenyl-2-thiohydantoin (DPTH) derivatives in vascular endothelial cells [J].

Cheng, Cheng-Kuo ;

Wu, Jender ;

Liu, Yuan ;

Lee, Tong-Sheng ;

Kang, Shuo-Jhen ;

Sheu, Ming-Thau ;

Lee, Wen-Sen .

VASCULAR PHARMACOLOGY, 2008, 48 (2-3) :138-142

[6] Reactivity of 2-thiohydantoins towards various electrophilic reagents:: Applications to the synthesis of new 2-ylidene-3,5-dihydro-4H-imidazol-4-ones. [J].

Chérouvrier, JR ;

Carreaux, F ;

Bazureau, JP .

MOLECULES, 2004, 9 (10) :867-875

[7]

Curran A. C. W., 1976, US Patent, Patent No. [3,984,430, 3984430]

[8] Synthesis of new thiazolidine and imidazolidine derivatives of pharmacological interest [J].

El-Aasar, Nadia K. ;

Saied, Khaled F. .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2008, 45 (03) :645-652

[9] Synthesis, characterization and derivatization of some novel types of mono- and bis-imidazolidineiminothiones and imidazolidineiminodithiones with antitumor, antiviral, antibacterial and antifungal activities - part I [J].

El-Sharief, Ahmed M. Sh. ;

Moussa, Ziad .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (11) :4315-4334

[10] S-GLUCOSYLATED HYDANTOINS AS NEW ANTIVIRAL AGENTS [J].

ELBARBARY, AA ;

KHODAIR, AI ;

PEDERSEN, EB ;

NIELSEN, C .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (01) :73-77

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