A review of the value of human epidermal growth factor receptor 2 (HER2)-targeted therapies in breast cancer

被引:23
作者
Nixon, N. A. [1 ]
Hannouf, M. B. [2 ,3 ]
Verma, S. [1 ]
机构
[1] Univ Calgary, Cumming Sch Med, Dept Oncol, 1331 29th St NW, Calgary, AB T2N 4N2, Canada
[2] Western Univ, Schulich Sch Med & Dent, Dept Epidemiol & Biostat, London, ON, Canada
[3] Western Univ, Ivey Sch Business, London, ON, Canada
关键词
Value; Cost-effectiveness; Human epidermal growth factor receptor-2 (HER2); Breast cancer; COST-EFFECTIVENESS ANALYSIS; ADJUVANT TRASTUZUMAB THERAPY; LAPATINIB PLUS CAPECITABINE; PHASE-III TRIAL; MONOCLONAL-ANTIBODY; ECONOMIC-EVALUATION; OPEN-LABEL; HER2; CHEMOTHERAPY; PERTUZUMAB;
D O I
10.1016/j.ejca.2017.10.037
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The cost of cancer drugs continues to escalate with the rapid development and approval of novel therapies, especially over the course of the last decade. In human epidermal growth factor receptor 2 (HER2)-positive breast cancer, the survival benefits gained by new treatments have been undeniably substantial. It is important to assess the financial value of these therapies for decision making at both the societal and individual level. This information is key for managing resources in resource-limited health care systems, while at the same time supporting patient decision-making and conversations between patient and physicians on cost versus benefit. In this article, we perform a systematic review of cost-effectiveness analyses that have been completed to date on HER2-targeted agents, focussing on those that correlate with standard of care therapy. Our discussion also highlights potential strategies to overcome several limitations associated with measuring value for anticancer drugs. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码:72 / 81
页数:10
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