A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers

被引：8
|
作者：
Fu, Yingjie [1 ,2 ]
Feng, Qishuai [3 ]
Shen, Yajing [3 ]
Chen, Mengwei [3 ]
Xu, Chang [3 ]
Cheng, Yu [3 ]
Zhou, Xiang [1 ,2 ]
机构：
[1] Wuhan Univ, Inst Adv Studies, Wuhan 430072, Hubei, Peoples R China
[2] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China
[3] Tongji Univ, Shanghai East Hosp, Inst Biomed Engn & Nano Sci, Sch Med, Shanghai 200029, Peoples R China
来源：
RSC ADVANCES | 2018年 / 8卷 / 11期
基金：
中国国家自然科学基金;
关键词：
DRUG-DELIVERY; MAMMALIAN-CELLS; SIZE; SHAPE; NANOSTRUCTURES; ENDOCYTOSIS; TOXICITY; TUMORS;
D O I：
10.1039/c7ra12735a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We designed and explored self-assembled gold nanoparticles (SAGNPs) by introducing dithiol modified polyethylene glycol (PEG) for internanoparticle cross-linking. SAGNPs could enhance uptake into cancer cells and be disintegrated by glutathione (GSH) to achieve tumor microenvironment-activated biodegradation. This assembled structure improved the photothermal effect compared to single gold nanospheres.
引用
收藏
页码：6120 / 6124
页数：5
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