Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock

被引：19

作者：

Wong, Hector R. ^{[1
,2
,3
]}

Walley, Keith R. ^{[4
,5
]}

Pettila, Ville ^{[6
]}

Meyer, Nuala J. ^{[7
]}

Russell, James A. ^{[4
,5
]}

Karlsson, Sari ^{[8
]}

Shashaty, Michael G. S. ^{[7
]}

Lindsell, Christopher J. ^{[9
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Div Crit Care Med, Cincinnati, OH 45229 USA

[2] Cincinnati Childrens Hosp Res Fdn, Cincinnati, OH USA

[3] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA

[4] Univ British Columbia, Ctr Heart Lung Innovat, Vancouver, BC V5Z 1M9, Canada

[5] St Pauls Hosp, Ctr Heart Lung Innovat, Crit Care Res Labs, Vancouver, BC V6Z 1Y6, Canada

[6] Univ Helsinki, Cent Hosp, Div Anaesthesia & Intens Care Med, Intens Care Units,Dept Surg, Helsinki, Finland

[7] Univ Penn, Perelman Sch Med, Div Pulm Allergy & Crit Care, Philadelphia, PA 19104 USA

[8] Tampere Univ Hosp, Dept Intens Care Med, Tampere, Finland

[9] Univ Cincinnati, Coll Med, Dept Emergency Med, Cincinnati, OH USA

来源：

BIOMARKERS | 2015年 / 20卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Biomarkers; decision tree; modeling; outcome; sepsis; stratification; PREDICTIVE-VALUE; INFECTION; MODEL;

D O I：

10.3109/1354750X.2014.1000971

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Context: We recently derived and validated a multi-biomarker-based model (ASSIST) to stratify patients with sepsis based on initial mortality risk. Objective: The objective of this study was to compare the performance of ASSIST to interleukin-6 (IL6) and procalcitonin (PCT). Methods: The area-under-the-receiver operating characteristic curve for predicting 28-d mortality using ASSIST was compared with that of IL6 (n = 452) and PCT (n = 235). Results: The area under the curve for ASSIST was greater than that of IL6 and PCT. Conclusions: ASSIST estimated the probability of mortality more reliably than IL6 and PCT in this cohort of patients with sepsis.

引用

页码：132 / 135

页数：4

共 18 条

[1] The pediatric sepsis biomarker risk model: potential implications for sepsis therapy and biology [J].

Alder, Matthew N. ;

Lindsell, Christopher J. ;

Wong, Hector R. .

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2014, 12 (07) :809-816

[2]

Dellinger RP, 2013, INTENS CARE MED, V41, P580, DOI [DOI 10.1097/CCM.0B013E31827E83AF, DOI 10.1007/s00134-012-2769-8]

[3] A METHOD OF COMPARING THE AREAS UNDER RECEIVER OPERATING CHARACTERISTIC CURVES DERIVED FROM THE SAME CASES [J].

HANLEY, JA ;

MCNEIL, BJ .

RADIOLOGY, 1983, 148 (03) :839-843

[4] Biomarker discovery and development in pediatric critical care medicine [J].

Kaplan, Jennifer M. ;

Wong, Hector R. .

PEDIATRIC CRITICAL CARE MEDICINE, 2011, 12 (02) :165-173

[5] Predictive value of procalcitonin decrease in patients with severe sepsis: a prospective observational study [J].

Karlsson, Sari ;

Heikkinen, Milja ;

Pettila, Ville ;

Alila, Seija ;

Vaisanen, Sari ;

Pulkki, Kari ;

Kolho, Elina ;

Ruokonen, Esko .

CRITICAL CARE, 2010, 14 (06)

[6] Multicategory reclassification statistics for assessing improvements in diagnostic accuracy [J].

Li, Jialiang ;

Jiang, Binyan ;

Fine, Jason P. .

BIOSTATISTICS, 2013, 14 (02) :382-394

[7] Special issue: Sepsis Gene expression profiling in sepsis: timing, tissue, and translational considerations [J].

Maslove, David M. ;

Wong, Hector R. .

TRENDS IN MOLECULAR MEDICINE, 2014, 20 (04) :204-213

[8] The Next Generation of Sepsis Clinical Trial Designs: What Is Next After the Demise of Recombinant Human Activated Protein C? [J].

Opal, Steven M. ;

Dellinger, R. Phillip ;

Vincent, Jean-Louis ;

Masur, Henry ;

Angus, Derek C. .

CRITICAL CARE MEDICINE, 2014, 42 (07) :1714-1721

[9] Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis The ACCESS Randomized Trial [J].

Opal, Steven M. ;

Laterre, Pierre-Francois ;

Francois, Bruno ;

LaRosa, Steven P. ;

Angus, Derek C. ;

Mira, Jean-Paul ;

Wittebole, Xavier ;

Dugernier, Thierry ;

Perrotin, Dominique ;

Tidswell, Mark ;

Jauregui, Luis ;

Krell, Kenneth ;

Pachl, Jan ;

Takahashi, Takeshi ;

Peckelsen, Claus ;

Cordasco, Edward ;

Chang, Chia-Sheng ;

Oeyen, Sandra ;

Aikawa, Naoki ;

Maruyama, Tatsuya ;

Schein, Roland ;

Kalil, Andre C. ;

Van Nuffelen, Marc ;

Lynn, Melvyn ;

Rossignol, Daniel P. ;

Gogate, Jogadish ;

Roberts, Mary B. ;

Wheeler, Janice L. ;

Vincent, Jean-Louis .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 309 (11) :1154-1162

[10] Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab1)2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels [J].

Panacek, EA ;

Marshall, JC ;

Albertson, TE ;

Johnson, DH ;

Johnson, S ;

MacArthur, RD ;

Miller, M ;

Barchuk, WT ;

Fischkoff, S ;

Kaul, M ;

Teoh, L ;

Van Meter, L ;

Daum, L ;

Lemeshow, S ;

Hicklin, G ;

Doig, C .

CRITICAL CARE MEDICINE, 2004, 32 (11) :2173-2182

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