Hyperkalemia in a Patient with Advanced Hepatocellular Carcinoma Probably Due to Sorafenib: Case Report

被引：0

作者：

Uyeturk, Ummugul ^{[1
]}

Budakoglu, Burcin ^{[1
]}

Helvaci, Kaan ^{[1
]}

Sonmez, Ozlem Uysal ^{[1
]}

Turker, Ibrahim ^{[1
]}

Arslan, Ulku Yalcintas ^{[1
]}

Oksuzoglu, Berna ^{[1
]}

Zengin, Nurullah ^{[1
]}

机构：

[1] Dr Abdurrahman Yurtarslan Oncol Training & Res Ho, Clin Med Oncol 2, Ankara, Turkey

来源：

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI | 2012年 / 32卷 / 02期

关键词：

Hepatocellular carcinoma; sorafenib; hyperkalemia; TUMOR LYSIS SYNDROME;

D O I：

10.5336/medsci.2010-21468

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sorafenib is an oral tyrosine kinase inhibitor used in the treatment of metastatic hepatocellular carcinoma (HCC). Its common adverse reactions include diarrhea, hand-foot syndrome, rash, cardiac ischemia or infarction, hypertension, elevated serum lipase and hypophosphatemia. A 35-year-old male patient with unresectable HCC was treated with sorafenib for progressive disease after locoregional chemoembolization. In the second month of the sorafenib treatment, he was admitted to the emergency department with weakness and drowsiness. His serum potassium level was 8.3 mmol/ L (3.5-5.5 mmol/L) which was accompanied with mild elevations in liver enzymes. Sorafenib treatment was stopped and emergency hemodialysis was applied. His potassium level reduced to normal levels and was stabilized.

引用

页码：585 / 587

页数：3

共 13 条

[1] ALBUTEROL AND INSULIN FOR TREATMENT OF HYPERKALEMIA IN HEMODIALYSIS-PATIENTS [J].

ALLON, M ;

COPKNEY, C .

KIDNEY INTERNATIONAL, 1990, 38 (05) :869-872

[2] Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial [J].

Cheng, Ann-Lii ;

Kang, Yoon-Koo ;

Chen, Zhendong ;

Tsao, Chao-Jung ;

Qin, Shukui ;

Kim, Jun Suk ;

Luo, Rongcheng ;

Feng, Jifeng ;

Ye, Shenglong ;

Yang, Tsai-Sheng ;

Xu, Jianming ;

Sun, Yan ;

Liang, Houjie ;

Liu, Jiwei ;

Wang, Jiejun ;

Tak, Won Young ;

Pan, Hongming ;

Burock, Karin ;

Zou, Jessie ;

Voliotis, Dimitris ;

Guan, Zhongzhen .

LANCET ONCOLOGY, 2009, 10 (01) :25-34

[3]

Diamantis ML, 2010, J DRUGS DERMATOL, V9, P169

[4] Sorafenib induced tumor lysis syndrome in an advanced hepatocellular carcinoma patient [J].

Huang, Wu-Shiung ;

Yang, Chang-Hsu .

WORLD JOURNAL OF GASTROENTEROLOGY, 2009, 15 (35) :4464-4466

[5] Sorafenib-induced multiple eruptive keratoacanthomas [J].

Jantzem, H. ;

Dupre-Goetghebeur, D. ;

Spindler, P. ;

Merrer, J. .

ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE, 2009, 136 (12) :894-897

[6] A Patient with Advanced Hepatocellular Carcinoma Treated with Sorafenib Tosylate Showed Massive Tumor Lysis with Avoidance of Tumor Lysis syndrome [J].

Joshita, Satoru ;

Yoshizawa, Kaname ;

Sano, Kenji ;

Kobayashi, Satoshi ;

Sekiguchi, Tomohiro ;

Morita, Susumu ;

Kamijo, Atsushi ;

Komatsu, Michiharu ;

Umemura, Takeji ;

Ichijo, Tetsuya ;

Matsumoto, Akihiro ;

Tanaka, Eiji .

INTERNAL MEDICINE, 2010, 49 (11) :991-994

[7] Sorafenib for the Treatment of Unresectable Hepatocellular Carcinoma [J].

Kane, Robert C. ;

Farrell, Ann T. ;

Madabushi, Rajanikanth ;

Booth, Brian ;

Chattopadhyay, Somesh ;

Sridhara, Rajeshwari ;

Justice, Robert ;

Pazdur, Richard .

ONCOLOGIST, 2009, 14 (01) :95-100

[8]

Karagol H, 2009, TURKIYE KLIN J MED O, V2, P19

[9] Sorafenib A Review of its Use in Advanced Hepatocellular Carcinoma [J].

Keating, Gillian M. ;

Santoro, Armando .

DRUGS, 2009, 69 (02) :223-240

[10] Sorafenib in advanced hepatocellular carcinoma [J].

Llovet, Josep M. ;

Ricci, Sergio ;

Mazzaferro, Vincenzo ;

Hilgard, Philip ;

Gane, Edward ;

Blanc, Jean-Frederic ;

Cosme de Oliveira, Andre ;

Santoro, Armando ;

Raoul, Jean-Luc ;

Forner, Alejandro ;

Schwartz, Myron ;

Porta, Camillo ;

Zeuzem, Stefan ;

Bolondi, Luigi ;

Greten, Tim F. ;

Galle, Peter R. ;

Seitz, Jean-Francois ;

Borbath, Ivan ;

Haussinger, Dieter ;

Giannaris, Tom ;

Shan, Minghua ;

Moscovici, Marius ;

Voliotis, Dimitris ;

Bruix, Jordi .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (04) :378-390

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