PET/CT Imaging in Mouse Models of Myocardial Ischemia

被引：22

作者：

Gargiulo, Sara ^{[1
,2
,3
]}

Greco, Adelaide ^{[1
,2
,3
]}

Gramanzini, Matteo ^{[1
,2
,3
]}

Petretta, Maria Piera ^{[1
,2
,4
]}

Ferro, Adele ^{[1
,2
]}

Larobina, Michele ^{[1
,2
]}

Panico, Mariarosaria ^{[1
,2
]}

Brunetti, Arturo ^{[1
,2
,3
]}

Cuocolo, Alberto ^{[1
,2
,3
]}

机构：

[1] Univ Naples Federico II, Dept Biomorphol & Funct Sci, I-80131 Naples, Italy

[2] Univ Naples Federico II, Inst Biostruct & Bioimages, Natl Res Council, I-80131 Naples, Italy

[3] CEINGE Biotecnol Avanzate Scarl, I-80145 Naples, Italy

[4] Univ Naples Federico II, Dept Internal Med Cardiovasc & Immunol Sci, I-80131 Naples, Italy

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2012年

关键词：

SMALL-ANIMAL PET; POSITRON-EMISSION-TOMOGRAPHY; MAXIMUM A-POSTERIORI; NONINVASIVE MEASUREMENT; ENDOTRACHEAL INTUBATION; PERFORMANCE EVALUATION; DIAGNOSTIC-ACCURACY; ANESTHETIC AGENTS; TC-99M SESTAMIBI; INPUT FUNCTION;

D O I：

10.1155/2012/541872

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Different species have been used to reproduce myocardial infarction models but in the last years mice became the animals of choice for the analysis of several diseases, due to their short life cycle and the possibility of genetic manipulation. Many techniques are currently used for cardiovascular imaging in mice, including X-ray computed tomography (CT), high-resolution ultrasound, magnetic resonance imaging, and nuclear medicine procedures. Cardiac positron emission tomography (PET) allows to examine noninvasively, on a molecular level and with high sensitivity, regional changes in myocardial perfusion, metabolism, apoptosis, inflammation, and gene expression or to measure changes in anatomical and functional parameters in heart diseases. Currently hybrid PET/CT scanners for small laboratory animals are available, where CT adds high-resolution anatomical information. This paper reviews mouse models of myocardial infarction and discusses the applications of dedicated PET/CT systems technology, including animal preparation, anesthesia, radiotracers, and images postprocessing.

引用

页数：12

共 66 条

[1] Quantitative imaging of myocardial infarct in rats with high resolution pinhole SPECT [J].