Na,K-ATPase and epithelial tight junctions

被引：48

作者：

Rajasekaran, Sigrid A. ^{[1
]}

Rajasekaran, Ayyappan K. ^{[1
]}

机构：

[1] Alfred I Dupont Hosp Children, Nemours Ctr Childhood Canc Res, Wilmington, DE 19803 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2009年 / 14卷

关键词：

Na; K-ATPase; alpha-subunit; beta-subunit; Tight Junction; polarity; FXYD; Occludin; Signaling; Review; GROWTH-FACTOR RECEPTOR; TUBE-SIZE CONTROL; NA-K-ATPASE; CELL-CELL-ADHESION; MOUSE PREIMPLANTATION DEVELOPMENT; REGULATES CLAUDIN EXPRESSION; SIGNAL-TRANSDUCING FUNCTION; DROSOPHILA TRACHEAL SYSTEM; TRANSCRIPTION FACTOR SNAIL; DOMAIN PROTEIN-1 MUPP1;

D O I：

10.2741/3367

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tight junctions are unique organelles in polarized epithelial and endothelial cells that regulate the flow of solutes and ions across the epithelial barrier. The structure and functions of tight junctions are regulated by a wide variety of signaling and molecular mechanisms. Several recent studies in mammals, drosophila, and zebrafish reported a new role for Na,K-ATPase, a well-studied ion transporter, in the modulation of tight junction development, permeability, and polarity. In this review, we have attempted to compile these new reports and suggest a model for a conserved role of Na,K-ATPase in the regulation of tight junction structure and functions.

引用

页码：2130 / 2148

页数：19

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