Solid-phase synthesis of 1,3-azole-based peptides and peptidomimetics

被引：48

作者：

Biron, Eric ^{[1
]}

Chatterjee, Jayanta ^{[1
]}

Kessler, Horst ^{[1
]}

机构：

[1] Tech Univ Munich, Dept Chem, Lehrstuhl Organ Chem 2, D-85747 Garching, Germany

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 11期

关键词：

D O I：

10.1021/ol0607645

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[graphics] We report highly efficient two-step procedures for the synthesis of 1,3-oxazole-, thiazole-, and imidazole- containing peptides on solid phase from dipeptides composed of C-terminal threonine, serine, cysteine, or diaminopropionic acid by using different cyclodehydration procedures followed or preceded by oxidation. The methods are compatible with Fmoc solid-phase peptide synthesis conditions and with N-Fmoc, N-Boc, N-Cbz, and N-Alloc protecting groups.

引用

页码：2416 / 2420

页数：4

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