Boosting the antitumor efficacy over a nanoscale porphyrin-based covalent organic polymer via synergistic photodynamic and photothermal therapy

被引：48
作者：
Liu, Sainan [1 ,2 ]
Liu, Ying [1 ]
Hu, Chunling [1 ]
Zhao, Xueyan [1 ]
Ma, Ping'an [1 ]
Pang, Maolin [1 ,2 ]
机构：
[1] Chinese Acad Sci, State Key Lab Rare Earth Resource Utilizat, Changchun Inst Appl Chem, Changchun 130022, Jilin, Peoples R China
[2] Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 44期
基金：
中国国家自然科学基金;
关键词：
SINGLET OXYGEN GENERATION; FE-SOC-MOF; FRAMEWORKS; COLLOIDOSOMES; CUBES; GA;
D O I：
10.1039/c9cc02345c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Porphyrin-based covalent organic polymer nanoparticles were synthesized via a Schiff base reaction at room temperature. The resulting product showed a good photodynamic effect and a high photothermal conversion efficiency (34.88%). Both in vitro and in vivo experiments demonstrated the enhanced antitumor efficacy via synergistic photodynamic and photothermal therapy.
引用
收藏
页码：6269 / 6272
页数：4
相关论文
共 43 条
[21]   Nanoparticles for photothermal therapies [J].
Jaque, D. ;
Martinez Maestro, L. ;
del Rosal, B. ;
Haro-Gonzalez, P. ;
Benayas, A. ;
Plaza, J. L. ;
Martin Rodriguez, E. ;
Garcia Sole, J. .
NANOSCALE, 2014, 6 (16) :9494-9530
[22]   Enhancement of Chemical Stability and Crystallinity in Porphyrin-Containing Covalent Organic Frameworks by Intramolecular Hydrogen Bonds [J].
Kandambeth, Sharath ;
Shinde, Digambar Balaji ;
Panda, Manas K. ;
Lukose, Binit ;
Heine, Thomas ;
Banerjee, Rahul .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (49) :13052-13056
[23]   Covalent organic frameworks comprising cobalt porphyrins for catalytic CO2 reduction in water [J].
Lin, Song ;
Diercks, Christian S. ;
Zhang, Yue-Biao ;
Kornienko, Nikolay ;
Nichols, Eva M. ;
Zhao, Yingbo ;
Paris, Aubrey R. ;
Kim, Dohyung ;
Yang, Peidong ;
Yaghi, Omar M. ;
Chang, Christopher J. .
SCIENCE, 2015, 349 (6253) :1208-1213
[24]   One-Pot Synthesis of DOX@Covalent Organic Framework with Enhanced Chemotherapeutic Efficacy [J].
Liu, Sainan ;
Hu, Chunling ;
Liu, Ying ;
Zhao, Xueyan ;
Pang, Maolin ;
Lin, Jun .
CHEMISTRY-A EUROPEAN JOURNAL, 2019, 25 (17) :4315-4319
[25]   Covalent Organic Frameworks: Structures, Synthesis, and Applications [J].
Lohse, Maria S. ;
Bein, Thomas .
ADVANCED FUNCTIONAL MATERIALS, 2018, 28 (33)
[26]   Targeted Drug Delivery in Covalent Organic Nanosheets (CONs) via Sequential Postsynthetic Modification [J].
Mitra, Shouvik ;
Sasmal, Himadri Sekhar ;
Kundu, Tanay ;
Kandambeth, Sharath ;
Math, Kavya ;
Diaz Diaz, David ;
Banerjee, Rahul .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2017, 139 (12) :4513-4520
[27]   Synthesis and Integration of Fe-soc-MOF Cubes into Colloidosomes via a Single-Step Emulsion-Based Approach [J].
Pang, Maolin ;
Cairns, Amy J. ;
Liu, Yunling ;
Belmabkhout, Youssef ;
Zeng, Hua Chun ;
Eddaoudi, Mohamed .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (28) :10234-10237
[28]   Highly Monodisperse MIII-Based soc-MOFs (M = In and Ga) with Cubic and Truncated Cubic Morphologies [J].
Pang, Maolin ;
Cairns, Amy J. ;
Liu, Yunling ;
Belmabkhout, Youssef ;
Zeng, Hua Chun ;
Eddaoudi, Mohamed .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (32) :13176-13179
[29]   Diketopyrrolopyrrole-Porphyrin Conjugates with High Two-Photon Absorption and Singlet Oxygen Generation for Two-Photon Photodynamic Therapy [J].
Schmitt, Julie ;
Heitz, Valerie ;
Sour, Angelique ;
Bolze, Frederic ;
Ftouni, Hussein ;
Nicoud, Jean-Francois ;
Flamigni, Lucia ;
Ventura, Barbara .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 54 (01) :169-173
[30]   Facile Fabrication of Nanoscale Porphyrinic Covalent Organic Polymers for Combined Photodynamic and Photothermal Cancer Therapy [J].
Shi, Yanshu ;
Liu, Sainan ;
Liu, Ying ;
Sun, Chunqiang ;
Chang, Mengyu ;
Zhao, Xueyan ;
Hu, Chunling ;
Pang, Maolin .
ACS APPLIED MATERIALS & INTERFACES, 2019, 11 (13) :12321-12326
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