Boosting the antitumor efficacy over a nanoscale porphyrin-based covalent organic polymer via synergistic photodynamic and photothermal therapy

被引：44
作者：
Liu, Sainan [1 ,2 ]
Liu, Ying [1 ]
Hu, Chunling [1 ]
Zhao, Xueyan [1 ]
Ma, Ping'an [1 ]
Pang, Maolin [1 ,2 ]
机构：
[1] Chinese Acad Sci, State Key Lab Rare Earth Resource Utilizat, Changchun Inst Appl Chem, Changchun 130022, Jilin, Peoples R China
[2] Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 44期
基金：
中国国家自然科学基金;
关键词：
SINGLET OXYGEN GENERATION; FE-SOC-MOF; FRAMEWORKS; COLLOIDOSOMES; CUBES; GA;
D O I：
10.1039/c9cc02345c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Porphyrin-based covalent organic polymer nanoparticles were synthesized via a Schiff base reaction at room temperature. The resulting product showed a good photodynamic effect and a high photothermal conversion efficiency (34.88%). Both in vitro and in vivo experiments demonstrated the enhanced antitumor efficacy via synergistic photodynamic and photothermal therapy.
引用
收藏
页码：6269 / 6272
页数：4
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