Boosting the antitumor efficacy over a nanoscale porphyrin-based covalent organic polymer via synergistic photodynamic and photothermal therapy

被引：48

作者：

Liu, Sainan ^{[1
,2
]}

Liu, Ying ^{[1
]}

Hu, Chunling ^{[1
]}

Zhao, Xueyan ^{[1
]}

Ma, Ping'an ^{[1
]}

Pang, Maolin ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, State Key Lab Rare Earth Resource Utilizat, Changchun Inst Appl Chem, Changchun 130022, Jilin, Peoples R China

[2] Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 44期

基金：

中国国家自然科学基金;

关键词：

SINGLET OXYGEN GENERATION; FE-SOC-MOF; FRAMEWORKS; COLLOIDOSOMES; CUBES; GA;

D O I：

10.1039/c9cc02345c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Porphyrin-based covalent organic polymer nanoparticles were synthesized via a Schiff base reaction at room temperature. The resulting product showed a good photodynamic effect and a high photothermal conversion efficiency (34.88%). Both in vitro and in vivo experiments demonstrated the enhanced antitumor efficacy via synergistic photodynamic and photothermal therapy.

引用

页码：6269 / 6272

页数：4

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