Non-alcoholic fatty liver disease and type 2 diabetes mellitus

被引：4

作者：

Par Alajos ^{[1
,2
]}

Wittmann Istvan ^{[2
]}

Par Gabriella ^{[1
]}

机构：

[1] Pecsi Tud Egyet, Altalanos Orvostud Kar, Klin Kozpont, Belgyogyaszati Klin 1, Pecs, Hungary

[2] Pecsi Tud Egyet, Altalanos Orvostud Kar, Klin Kozpont, Belgyogyaszati Klin & Nephrol 2,Diabetol Ctr, Pecs, Hungary

来源：

ORVOSI HETILAP | 2022年 / 163卷 / 21期

关键词：

non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; diabetes mellitus; pathogenesis; EXOME-WIDE ASSOCIATION; INSULIN-RESISTANCE; CONFERS SUSCEPTIBILITY; GENETIC-VARIATION; FIBROSIS; STEATOHEPATITIS; VARIANT; PNPLA3; RISK; PATHOPHYSIOLOGY;

D O I：

10.1556/650.2022.32479

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease, affecting 25% of world population. NAFLD and its progressive subphenotype, non-alcoholic steatohepatitis (NASH) are prevalent in obese individuals, and also frequently coexist with type 2 diabetes mellitus (DM). NAFLD is associated with a 2- to 3-fold increased risk of developing DM, that parallels with the severity of liver disease. NAFLD and diabetes act synergistically increasing the risk of adverse clinical outcomes. Patients with diabetes frequently have fatty liver, and diabetes is a strong predictor of the progression of NAFLD to NASH or to fibrosis and cirrhosis. Genetic factors, and increased caloric intake, dysfunctional adipose tissue, insulin resistance, free fatty acids, proinflammatory cytokines, lipotoxicity and glucotoxicity play a pivotal role in the development of NAFLD and diabetes. In this review we describe the pathogenetic mechanisms that mirror the complex causal link between these two metabolic diseases.

引用

页码：815 / 825

页数：11

共 59 条

[1] Significant fibrosis predicts new-onset diabetes mellitus and arterial hypertension in patients with NASH [J].

Ampuero, Javier ;

Aller, Rocio ;

Gallego-Duran, Rocio ;

Crespo, Javier ;

Luis Calleja, Jose ;

Garcia-Monzon, Carmelo ;

Gomez-Camarero, Judith ;

Caballeria, Joan ;

Lo Iacono, Oreste ;

Ibanez, Luis ;

Garcia-Samaniego, Javier ;

Albillos, Agustin ;

Frances, Ruben ;

Fernandez-Rodriguez, Conrado ;

Diago, Moises ;

Soriano, German ;

Andrade, Raul J. ;

Latorre, Raquel ;

Jorquera, Francisco ;

Morillas, Rosa Maria ;

Escudero, Desamparados ;

Estevez, Pamela ;

Hernandez Guerra, Manuel ;

Augustin, Salvador ;

Banales, Jesus M. ;

Aspichueta, Patricia ;

Benlloch, Salvador ;

Miguel Rosales, Jose ;

Salmeron, Javier ;

Turnes, Juan ;

Romero-Gomez, Manuel .

JOURNAL OF HEPATOLOGY, 2020, 73 (01) :17-25

[2] The genetics of NAFLD [J].

Anstee, Quentin M. ;

Day, Christopher P. .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2013, 10 (11) :645-655

[3] Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis [J].

BasuRay, Soumik ;

Wang, Yang ;

Smagris, Eriks ;

Cohen, Jonathan C. ;

Hobbs, Helen H. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (19) :9521-9526

[4] Histologic Scores for Fat and Fibrosis Associate With Development of Type 2 Diabetes in Patients With Nonalcoholic Fatty Liver Disease [J].

Bjorkstrom, Karl ;

Stal, Per ;

Hultcrantz, Rolf ;

Hagstrom, Hannes .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2017, 15 (09) :1461-1468

[5] NAFLD: A multisystem disease [J].

Byrne, Christopher D. ;

Targher, Giovanni .

JOURNAL OF HEPATOLOGY, 2015, 62 :S47-S64

[6] Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Medical Care in Diabetes-2019 [J].

Cefalu, William T. ;

Berg, Erika Gebel ;

Saraco, Mindy ;

Petersen, Matthew P. ;

Uelmen, Sacha ;

Robinson, Shamera .

DIABETES CARE, 2019, 42 :S34-S45

[7] The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases [J].

Chalasani, Naga ;

Younossi, Zobair ;

Lavine, Joel E. ;

Charlton, Michael ;

Cusi, Kenneth ;

Rinella, Mary ;

Harrison, Stephen A. ;

Brunt, Elizabeth M. ;

Sanyal, Arun J. .

HEPATOLOGY, 2018, 67 (01) :328-357

[8] Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies [J].

Del Prato, S. .

DIABETIC MEDICINE, 2009, 26 (12) :1185-1192

[9] Transmembrane 6 Superfamily Member 2 Gene Variant Disentangles Nonalcoholic Steatohepatitis From Cardiovascular Disease [J].

Dongiovanni, Paola ;

Petta, Salvatore ;

Maglio, Cristina ;

Fracanzani, Anna Ludovica ;

Pipitone, Rosaria ;

Mozzi, Enrico ;

Motta, Benedetta Maria ;

Kaminska, Dorota ;

Rametta, Raffaela ;

Grimaudo, Stefania ;

Pelusi, Serena ;

Montalcini, Tiziana ;

Alisi, Anna ;

Maggioni, Marco ;

Karja, Vesa ;

Boren, Jan ;

Kakela, Pirjo ;

Di Marco, Vito ;

Xing, Chao ;

Nobili, Valerio ;

Dallapiccola, Bruno ;

Craxi, Antonio ;

Pihlajamaki, Jussi ;

Fargion, Silvia ;

Sjostrom, Lars ;

Carlsson, Lena M. ;

Romeo, Stefano ;

Valenti, Luca .

HEPATOLOGY, 2015, 61 (02) :506-514

[10]

EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]

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