Prediction of Human Pharmacokinetics in 2013 and Beyond

被引：6
作者：
Houston, J. Brian [1 ]
机构：
[1] Univ Manchester, Manchester Pharm Sch, Ctr Appl Pharmacokinet Res, Manchester M13 9PT, Lancs, England
来源：
DRUG METABOLISM AND DISPOSITION | 2013年 / 41卷 / 12期
关键词：
DISPOSITION; METABOLISM;
D O I：
10.1124/dmd.113.055376
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The utility of in vitro generated kinetic data to provide quantitative prediction of in vivo pharmacokinetic behavior is well established and forms a cornerstone of many research projects in drug metabolism and disposition, particularly within the pharmaceutical industry. This issue provides several excellent examples of the use of in vitro techniques for prediction of human pharmacokinetics (PK). The general area of in vitro-in vivo extrapolation (IVIVE) is broad and hence the spectrum of topics covers various aspects drug clearance and distribution and drug-drug interactions. Some articles were commissioned whereas others were identified during the reviewing process. Overall they provide a snapshot of activity at the end of 2013. They document that whereas the translation of some in vitro approaches is now established, other areas are in their infancy and need more development.
引用
收藏
页码：1973 / 1974
页数：2
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