One load to rule them all: Mechanical control of the musculoskeletal system in development and aging

被引：45

作者：

Shwartz, Yulia ^{[1
]}

Blitz, Einat ^{[1
]}

Zelzer, Elazar ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

来源：

DIFFERENTIATION | 2013年 / 86卷 / 03期

关键词：

Musculoskeletal system; Mechanobiology; Mechanoregulation; Mechanotransduction; Skeletogenesis; MESENCHYMAL STEM-CELLS; SYNOVIAL JOINT FORMATION; MUTATION MUSCULAR DYSGENESIS; TRANSPLANTED LIMB PRIMORDIA; PATELLAR TENDON FIBROBLASTS; ESTROGEN-RECEPTOR-ALPHA; BONE-MINERAL DENSITY; SKELETAL-MUSCLE; CHICK-EMBRYO; ARTICULAR-CARTILAGE;

D O I：

10.1016/j.diff.2013.07.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The musculoskeletal system functions because of the precise and coordinated assembly of its components, namely bones and joints, muscles, tendons and ligaments. This coordination requires cross-talk between the tissues, which is mediated by various molecular and mechanical cues. In this review, we summarize the progress that has been made in understanding the involvement of mechanical loads exerted by the musculature in the development of skeletal and tendinous tissues, in their integration into one functional unit and in the maintenance of this system. In addition, we discuss the possible role of muscle load in aging and propose new directions for future studies of the musculoskeletal system. (c) 2013 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.

引用

页码：104 / 111

页数：8

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