Structure of CTLA-4 complexed with a pH-sensitive cancer immunotherapeutic antibody

被引:7
作者
Gao, Han [1 ,2 ]
Cai, Haiyan [3 ]
Liu, Jia [4 ]
Wang, Xiaoxiao [4 ,5 ]
Zheng, Pan [6 ]
Devenport, Martin [6 ]
Xu, Ting [4 ,5 ]
Dou, Fei [1 ,2 ]
Liu, Yang [6 ]
Zhou, Aiwu [3 ]
机构
[1] Beijing Normal Univ, Coll Life Sci, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
[2] Beijing Normal Univ, Coll Life Sci, Beijing Key Lab Genet Engn Drugs & Biotechnol, Beijing 100875, Peoples R China
[3] Shanghai Jiao Tong Univ, Key Lab Cell Differentiat & Apoptosis, Chinese Minist Educ, Dept Pathophysiol,Sch Med, Shanghai 200025, Peoples R China
[4] Southeast Univ, Sch Life Sci & Technol, Nanjing 210096, Jiangsu, Peoples R China
[5] Alphamab Co Ltd, Suzhou 215125, Jiangsu, Peoples R China
[6] OncoImmune Inc, Rockville, MD 20850 USA
基金
中国国家自然科学基金;
关键词
REGULATORY T-CELLS; DEPLETION; BLOCKADE; THERAPY;
D O I
10.1038/s41421-020-00202-9
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页数:4
相关论文
共 13 条
  • [1] A NEW MEMBER OF THE IMMUNOGLOBULIN SUPERFAMILY - CTLA-4
    BRUNET, JF
    DENIZOT, F
    LUCIANI, MF
    ROUXDOSSETO, M
    SUZAN, M
    MATTEI, MG
    GOLSTEIN, P
    [J]. NATURE, 1987, 328 (6127) : 267 - 270
  • [2] A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy
    Du, Xuexiang
    Tang, Fei
    Liu, Mingyue
    Su, Juanjuan
    Zhang, Yan
    Wu, Wei
    Devenport, Martin
    Lazarski, Christopher A.
    Zhang, Peng
    Wang, Xu
    Ye, Peiying
    Wang, Changyu
    Hwang, Eugene
    Zhu, Tinghui
    Xu, Ting
    Zheng, Pan
    Liu, Yang
    [J]. CELL RESEARCH, 2018, 28 (04) : 416 - 432
  • [3] Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice
    Du, Xuexiang
    Liu, Mingyue
    Su, Juanjuan
    Zhang, Peng
    Tang, Fei
    Ye, Peiying
    Devenport, Martin
    Wang, Xu
    Zhang, Yan
    Liu, Yang
    Zheng, Pan
    [J]. CELL RESEARCH, 2018, 28 (04) : 433 - 447
  • [4] Ipilimumab and Its Toxicities: A Multidisciplinary Approach
    Fecher, Leslie A.
    Agarwala, Sanjiv S.
    Hodi, F. Stephen
    Weber, Jeffrey S.
    [J]. ONCOLOGIST, 2013, 18 (06) : 733 - 743
  • [5] Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
    Hodi, F. Stephen
    O'Day, Steven J.
    McDermott, David F.
    Weber, Robert W.
    Sosman, Jeffrey A.
    Haanen, John B.
    Gonzalez, Rene
    Robert, Caroline
    Schadendorf, Dirk
    Hassel, Jessica C.
    Akerley, Wallace
    van den Eertwegh, Alfons J. M.
    Lutzky, Jose
    Lorigan, Paul
    Vaubel, Julia M.
    Linette, Gerald P.
    Hogg, David
    Ottensmeier, Christian H.
    Lebbe, Celeste
    Peschel, Christian
    Quirt, Ian
    Clark, Joseph I.
    Wolchok, Jedd D.
    Weber, Jeffrey S.
    Tian, Jason
    Yellin, Michael J.
    Nichol, Geoffrey M.
    Hoos, Axel
    Urba, Walter J.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (08) : 711 - 723
  • [6] CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
    Krummel, MF
    Allison, JP
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (06) : 2533 - 2540
  • [7] How Does an Anti-CTLA-4 Antibody Promote Cancer Immunity?
    Liu, Yang
    Zheng, Pan
    [J]. TRENDS IN IMMUNOLOGY, 2018, 39 (12) : 953 - 956
  • [8] Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy
    Lo, Bernice
    Zhang, Kejian
    Lu, Wei
    Zheng, Lixin
    Zhang, Qian
    Kanellopoulou, Chrysi
    Zhang, Yu
    Liu, Zhiduo
    Fritz, Jill M.
    Marsh, Rebecca
    Husami, Ammar
    Kissell, Diane
    Nortman, Shannon
    Chaturvedi, Vijaya
    Haines, Hilary
    Young, Lisa R.
    Mo, Jun
    Filipovich, Alexandra H.
    Bleesing, Jack J.
    Mustillo, Peter
    Stephens, Michael
    Rueda, Cesar M.
    Chougnet, Claire A.
    Hoebe, Kasper
    McElwee, Joshua
    Hughes, Jason D.
    Karakoc-Aydiner, Elif
    Matthews, Helen F.
    Price, Susan
    Su, Helen C.
    Rao, V. Koneti
    Lenardo, Michael J.
    Jordan, Michael B.
    [J]. SCIENCE, 2015, 349 (6246) : 436 - 440
  • [9] Cancer immunotherapy comes of age
    Mellman, Ira
    Coukos, George
    Dranoff, Glenn
    [J]. NATURE, 2011, 480 (7378) : 480 - 489
  • [10] Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4
    Qureshi, Omar S.
    Zheng, Yong
    Nakamura, Kyoko
    Attridge, Kesley
    Manzotti, Claire
    Schmidt, Emily M.
    Baker, Jennifer
    Jeffery, Louisa E.
    Kaur, Satdip
    Briggs, Zoe
    Hou, Tie Z.
    Futter, Clare E.
    Anderson, Graham
    Walker, Lucy S. K.
    Sansom, David M.
    [J]. SCIENCE, 2011, 332 (6029) : 600 - 603