Surface-mediated proton-transfer reactions in membrane-bound proteins

被引：81
作者：
Ädelroth, P [1 ]
Brzezinski, P [1 ]
机构：
[1] Stockholm Univ, Arrhenius Labs Nat Sci, Dept Biochem & Biophys, SE-10691 Stockholm, Sweden
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2004年 / 1655卷 / 1-3期
关键词：
proton pathway; cytochrome c oxidase; reaction centre; photosynthesis; respiration; electron transfer; kinetics;
D O I：
10.1016/j.bbabio.2003.10.018
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
As Outlined by Peter Mitchell in the chemiosmotic theory, an intermediate in energy conversion in biological systems is a proton electrochemical potential difference ("proton gradient") across a membrane, generated by membrane-bound protein complexes. These protein complexes accommodate proton-transfer pathways through which protons are conducted. In this review, we focus specifically on the role of the protein-membrane surface and the surface-bulk water interface in the dynamics of proton delivery to these proton-transfer pathways. The general mechanisms are illustrated by experimental results from studies of bacterial photosynthetic reaction centres (RCs) and cytochrome e oxidase (CcO). (C) 2004 Elsevier B.V. All rights reserved.
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收藏
页码：102 / 115
页数：14
相关论文
共 85 条
[1]   Inhibition of proton transfer in cytochrome c oxidase by zinc ions:: delayed proton uptake during oxygen reduction [J].
Aagaard, A ;
Namslauer, A ;
Brzezinski, P .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2002, 1555 (1-3) :133-139
[2]   Zinc ions inhibit oxidation of cytochrome c oxidase by oxygen [J].
Aagaard, A ;
Brzezinski, P .
FEBS LETTERS, 2001, 494 (03) :157-160
[3]   Identification of proton transfer pathways in the X-ray crystal structure of the bacterial reaction center from Rhodobacter sphaeroides [J].
Abresch, EC ;
Paddock, ML ;
Stowell, MHB ;
McPhillips, TM ;
Axelrod, HL ;
Soltis, SM ;
Rees, DC ;
Okamura, MY ;
Feher, G .
PHOTOSYNTHESIS RESEARCH, 1998, 55 (2-3) :119-125
[4]   Identification of the proton pathway in bacterial reaction centers:: Both protons associated with reduction of QB to QBH2 share a common entry point [J].
Ädelroth, P ;
Paddock, ML ;
Sagle, LB ;
Feher, G ;
Okamura, MY .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (24) :13086-13091
[5]   Factors determining electron-transfer rates in cytochrome c oxidase:: investigation of the oxygen reaction in the R-sphaeroides enzyme [J].
Ädelroth, P ;
Ek, M ;
Brzezinski, P .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1998, 1367 (1-3) :107-117
[6]   Identification of the proton pathway in bacterial reaction centers:: Decrease of proton transfer rate by mutation of surface histidines at H126 and H128 and chemical rescue by imidazole identifies the initial proton donors [J].
Ädelroth, P ;
Paddock, ML ;
Tehrani, A ;
Beatty, JT ;
Feher, G ;
Okamura, MY .
BIOCHEMISTRY, 2001, 40 (48) :14538-14546
[7]   Proton transfer from glutamate 286 determines the transition rates between oxygen intermediates in cytochrome c oxidase [J].
Ådelroth, P ;
Karpefors, M ;
Gilderson, G ;
Tomson, FL ;
Gennis, RB ;
Brzezinski, P .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2000, 1459 (2-3) :533-539
[8]   RAPID LONG-RANGE PROTON DIFFUSION ALONG THE SURFACE OF THE PURPLE MEMBRANE AND DELAYED PROTON-TRANSFER INTO THE BULK [J].
ALEXIEV, U ;
MOLLAAGHABABA, R ;
SCHERRER, P ;
KHORANA, HG ;
HEYN, MP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (02) :372-376
[9]   Determination of the binding sites of the proton transfer inhibitors Cd2+ and Zn2+ in bacterial reaction centers [J].
Axelrod, HL ;
Abresch, EC ;
Paddock, ML ;
Okamura, MY ;
Feher, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (04) :1542-1547
[10]   OXYGEN ACTIVATION AND THE CONSERVATION OF ENERGY IN CELL RESPIRATION [J].
BABCOCK, GT ;
WIKSTROM, M .
NATURE, 1992, 356 (6367) :301-309
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