New highly active taxoids from 9β-dihydrobaccatin-9,10-acetals

被引：18

作者：

Ishiyama, T ^{[1
]}

Iimura, S ^{[1
]}

Ohsuki, S ^{[1
]}

Uoto, K ^{[1
]}

Terasawa, H ^{[1
]}

Soga, T ^{[1
]}

机构：

[1] Daiichi Pharmaceut Co Ltd, Tokyo R&D Ctr, Med Chem Res Lab, Edogawa Ku, Tokyo 1348630, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(02)00069-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

To synthesize new highly active taxoids, we designed and synthesized 9beta-dihydro-9,10-acetal taxoids. In vitro study of these analogues clearly showed them to be more potent than docetaxel. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1083 / 1086

页数：4

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