AML1/RUNX1 MUTATIONS ARE FREQUENT IN DE NOVO AML WITH CERTAIN CYTOGENETICS AND COOPERATING MOLECULAR MUTATIONS DIFFER DEPENDENT ON UNDERLYING CYTOGENETICS

被引:0
作者
Schnittger, S. [1 ]
Dicker, E. [1 ]
Kern, W. [1 ]
Haferlach, T. [1 ]
Haferlach, C. [1 ]
机构
[1] MLL Munich Leukemia Lab, Munich, Germany
来源
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2008年 / 93卷
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
0019
引用
收藏
页码:8 / 8
页数:1
相关论文
共 50 条
[41]   IDENTIFICATION OF PATTERNS IN CO-OCCURRING MUTATIONS IN AML PATIENTS WITH GERMLINE AND SOMATIC RUNX1 MUTATIONS [J].
Borate, U. ;
Wilmot, B. ;
Norris, B. ;
Lo, P. ;
Bottomly, D. ;
McWeeney, S. ;
Tyner, J. ;
Agarwal, A. .
HAEMATOLOGICA, 2017, 102 :44-45
[42]   ETV6/RUNX1 (TEL/AML1) is a frequent prenatal first hit in childhood leukemia [J].
Zuna, Jan ;
Madzo, Jozef ;
Krejci, Ondrej ;
Zemanova, Zuzana ;
Kalinova, Marketa ;
Muzikova, Katerina ;
Zapotocky, Michal ;
Starkova, Julia ;
Hrusak, Ondrej ;
Horak, Jiri ;
Trka, Jan .
BLOOD, 2011, 117 (01) :368-369
[43]   Different patterns of AML1 mutations between de novo Myelodysplastic syndrome and chronic myelomonocystic leukemia [J].
Shih, Lee-Yung ;
Liang, Der-Cherng ;
Huang, Chein-Fuang ;
Kuo, Ming-Chung ;
Lin, Tung-Liang ;
Fu, Jen-Fen ;
Shih, Yu-Shu ;
Wu, Jin-Hou ;
Wang, Po-Nan ;
Dunn, Po ;
Tang, Tzung-Chih ;
Chang, Hung .
BLOOD, 2007, 110 (11) :720A-720A
[44]   Trisomy 13 is strongly associated with AML1/RUNX1 mutations and increased FLT3 expression in acute myeloid leukemia [J].
Dicker, Frank ;
Haferlach, Claudia ;
Kern, Wolfgang ;
Haferlach, Torsten ;
Schnittger, Susanne .
BLOOD, 2007, 110 (04) :1308-1316
[45]   High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia [J].
Harada, H ;
Harada, Y ;
Niimi, H ;
Kyo, T ;
Kimura, A ;
Inaba, T .
BLOOD, 2004, 103 (06) :2316-2324
[46]   Generation of novel knockin mouse lines harboring leukemia-associated point mutations at AML1/Runx1 gene locus [J].
Fukushime-Nakase, Y ;
Nakao, M ;
Sugimoto, T ;
Okuda, T .
BLOOD, 2004, 104 (11) :136A-136A
[47]   Mice with AML1 (Runx1) haploinsufficiency have significant platelet abnormalities that accurately mimic those seen in human patients with germ line inactivating mutations in AML1. [J].
Sun, WL ;
Steward, S ;
Pestina, T ;
Jackson, CW ;
Downing, JR .
BLOOD, 2004, 104 (11) :444A-444A
[48]   Molecular basis for a dominant inactivation of RUNX1/AML1 by the leukemogenic inversion 16 chimera. [J].
Gang, H ;
Osato, M ;
Shigesada, K ;
Liu, PP ;
Ito, Y .
BLOOD, 2002, 100 (11) :534A-534A
[49]   ASXL1 mutations are frequent in de novo AML with trisomy 8 and confer an unfavorable prognosis [J].
Zong, Xiangping ;
Yao, Hong ;
Wen, Lijun ;
Ma, Liang ;
Wang, Qinrong ;
Yang, Zhiluo ;
Zhang, Tongtong ;
Chen, Suning ;
Wu Depei .
LEUKEMIA & LYMPHOMA, 2017, 58 (01) :204-206
[50]   RUNX1 MUTATIONS IN DE NOVO MDS AND CMML AT BOTH DIAGNOSIS AND AML TRANSFORMATION: A COMPARATIVE ANALYSIS ON 80 MATCHED PAIRED MARROW SAMPLES [J].
Kuo, M. -C ;
Liang, D. -C ;
Huang, C. -F ;
Shih, Y. -S ;
Lin, T. -L ;
Wu, J. -H. ;
Shih, L. -Y. .
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 :102-102