AML1/RUNX1 MUTATIONS ARE FREQUENT IN DE NOVO AML WITH CERTAIN CYTOGENETICS AND COOPERATING MOLECULAR MUTATIONS DIFFER DEPENDENT ON UNDERLYING CYTOGENETICS

被引：0
作者：
Schnittger, S. [1 ]
Dicker, E. [1 ]
Kern, W. [1 ]
Haferlach, T. [1 ]
Haferlach, C. [1 ]
机构：
[1] MLL Munich Leukemia Lab, Munich, Germany
来源：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2008年 / 93卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
0019
引用
收藏
页码：8 / 8
页数：1
相关论文
共 50 条
  • [21] AML with RUNX1::RUNX1T1 Cooperating two Mutations Relapsed Quickly after Achieving CR
    Yang, Xinhong
    Wu, Yingwei
    Yang, Xiaofeng
    Wu, Xue
    Chen, Yingying
    Zhang, Rongjuan
    Zhang, Zhihua
    CLINICAL LABORATORY, 2024, 70 (03) : 619 - 621
  • [22] RUNX1 Mutations in MDS, s-AML and De Novo AML: Differences in Accompanying Cytogenetic and Molecular Genetic Alterations, Clonal Architecture and Outcome
    Stengel, Anna
    Kern, Wolfgang
    Meggendorfer, Manja
    Haferlach, Torsten
    Haferlach, Claudia
    BLOOD, 2017, 130
  • [23] AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations
    Tang, Jih-Luh
    Hou, Hsin-An
    Chen, Chien-Yuan
    Liu, Chieh-Yu
    Chou, Wen-Chien
    Tseng, Mei-Hsuan
    Huang, Chi-Fei
    Lee, Fen-Yu
    Liu, Ming-Chih
    Yao, Ming
    Huang, Shang-Yi
    Ko, Bor-Sheng
    Hsu, Szu-Chun
    Wu, Shang-Ju
    Tsay, Woei
    Chen, Yao-Chang
    Lin, Liang-In
    Tien, Hwei-Fang
    BLOOD, 2009, 114 (26) : 5352 - 5361
  • [24] The Number of RUNX1 Mutations and the Presence of One Intact RUNX1 Allele Influence Cytogenetic Abnormalities, Additional Molecular Mutations and Prognosis in RUNX1 Mutated AML
    Stengel, Anna
    Kern, Wolfgang
    Meggendorfer, Manja
    Perglerova, Karolina
    Haferlach, Torsten
    Haferlach, Claudia
    BLOOD, 2016, 128 (22)
  • [25] AML with RUNX1 Mutations and Loss of RUNX1 Wild-Type - a Distinct Subset?
    Haferlach, Claudia
    Nadarajah, Niroshan
    Fasan, Annette
    Perglerova, Karolina
    Kern, Wolfgang
    Schnittger, Susanne
    Haferlach, Torsten
    BLOOD, 2015, 126 (23)
  • [26] Implications of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome (MDS):: Future molecular therapeutic directions for MDS
    Harada, Hironori
    Harada, Yuka
    Kimura, Akiro
    CURRENT CANCER DRUG TARGETS, 2006, 6 (06) : 553 - 563
  • [27] AML1/RUNX1 Mutations in 470 Adult Patients with De Novo Acute Myeloid Leukemia: Prognostic Implication and Interaction with Other Gene Alterations.
    Hou, Hsin An
    Tang, Jih-Luh
    Lin, Liang-In
    Chen, Chien-Yuan
    Chou, Wen-Chien
    Tseng, Mei-Hsuan
    Huang, Chi-Fei
    Lee, Fen-Yu
    Liu, Ming-Chih
    Yao, Ming
    Huang, Shang-Yi
    Ko, Bo-Sheng
    Hsu, Szu-Chun
    Wu, Shang-Ju
    Tsai, Woei
    Chen, Yao-Chang
    Tien, Hwei-Fang
    BLOOD, 2009, 114 (22) : 626 - 626
  • [28] Examination of RUNX1::RUNXT1 in AML: RNA versus Cytogenetics, Flow Cytometry, and Morphology
    Williams-Watley, M.
    Ollila, P.
    Carbajal, S.
    Viswanatha, D.
    He, R.
    JOURNAL OF MOLECULAR DIAGNOSTICS, 2023, 25 (11) : S43 - S43
  • [29] High frequency of germline RUNX1 mutations in patients with RUNX1-mutated AML
    Simon, Laura
    Spinella, Jean-Francois
    Yao, Chi-Yuan
    Lavallee, Vincent-Philippe
    Boivin, Isabel
    Boucher, Genevieve
    Audemard, Eric
    Bordeleau, Marie-Eve
    Lemieux, Sebastien
    Hebert, Josee
    Sauvageau, Guy
    BLOOD, 2020, 135 (21) : 1882 - 1886
  • [30] In AML Secondary to MDS NPM1 Mutations Are Late Events, Less Frequent, and Associated with a Different Pattern of Molecular Mutations Than in De Novo AML
    Schnittger, Susanne
    Haferlach, Claudia
    Nadarajah, Niroshan
    Alpermann, Tamara
    Meggendorfer, Manja
    Perglerova, Karolina
    Kern, Wolfgang
    Haferlach, Torsten
    BLOOD, 2014, 124 (21)
12345